2型糖尿病合并OSAHS患者血清3-NT水平的变化及影响因素  

Changes of serum 3-NT and its influencing factors in patients with T2DM and OSAHS

作　　者：陈璐[1] 王龙[1] 华飞[1] 唐暎[1] 张秋娣[2] 徐茵[1] 蒋晓红[1] 

机构地区：[1]苏州大学附属第三医院内分泌病科,江苏省213003 [2]苏州大学附属第三医院呼吸病科,江苏省213003

出　　处：《江苏医药》2015年第17期2006-2008,2013,共4页Jiangsu Medical Journal

基　　金：国家自然青年科学基金(81300687);常州市卫生科研资助项目(WZ201203)

摘　　要：目的观察2型糖尿病(T2DM)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清3-硝基酪氨酸(3-NT)水平的变化及其影响因素。方法根据呼吸暂停低通气指数(AHI),70例T2DM合并OSAHS患者(TO组)分为轻度组(5次/h≤AHI<15次/h,26例)、中度组(15次/h≤AHI<30次/h,16例)和重度组(AHI≥30次/h,28例);另选取健康人50例作为对照(NC组)。采用ELISA检测血清3-NT水平,比较相关资料。结果与NC组相比,TO组各亚组的糖化血红蛋白(HbA1c)、空腹血糖(FBG)、三酰甘油(TG)、尿酸(UA)和血清3-NT均增高(P<0.05)。重度组的HbA1c、3-NT和UA水平高于轻、中度组(P<0.05)。与重度组比较,轻、中度组氧减指数(ODI)值较低,最低血氧饱和度(LSO2)和平均血氧饱和度(MSO2)水平较高(P<0.05)。血清3-NT与FBG、HbA1c、AHI和ODI值呈正相关(rs=0.445、0.466、0.897、0.813,P<0.01),与LSO2、MSO2水平呈负相关(rs=-0.473、-0.434,P<0.01)。结论 T2DM合并OSAHS患者血清3-NT水平高于正常人群,且随AHI升高而增高。血清3-NT水平与血糖水平和间歇性缺氧程度都存在明显相关性。Objective To observe the changes of serum 3-nitrotyrosine （3-NT）and its influencing factors in the patients with obstructive sleep apnea-hypopnea syndrome（OSAHS） and type 2 diabetes（T2DM）. Methods On the basis of apnea-hypopnea index （AHI）, 70 patients with OSAHS and T2DM（group TO） were divided into three groups of O1 （5 times per hour≤AHI 〈15 times per hour,26 cases）,O2（15 times per hour≤AHI〈30 times per hour, 16 cases） and 03 （AHI≥30 times per hour, 28 cases）. Fifty healthy people were taken as the controls（group NC）. Serum levels of 3-NT were determined by ELISA and relevant data were compared. Results The levels of glycosylated hemoglobin lc （HbAlc）, fasting blood glucose （FBG）, triglyceride （TG） and 3-NT were significantly higher in groups of TO1 ,TO2 and TO3 than those in group NC（P〈0. 05）. The levels of HbAlc, 3 NT and UA were higher in group 03 than those in groups of O1 and 02 （P〈0. 05）. Compared with group TO3, the levels of oxygen desaturation index（ODI） were lower, the lowest oxygen saturation（LSOz ） and mean oxygen saturation（MSOz ） were higher in groups of TO1 and TO2（P〈0. 05）. Serum level of 3-NT was positively correlated with FBG, HbAlc, AHI and ODI （r1=0. 445, 0.466, 0. 897, and 0. 813, P〈0. 01）, but negatively correlated with LSO2 and MSO2 （r1=-0. 473 and -0. 434, P〈0. 01）. Conclusion Serum 3-NT is higher in the patients with OSAHS and T2DM than normal healthy people, which increases as AHI increases. Serum level of 3-NT is closely correlated with the level of blood glucose and the severity of intermittent hypoxia.

关 键 词：3-硝基酪氨酸 2型糖尿病 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R587[医药卫生—内分泌]