I型NKT细胞在支气管哮喘发病机制中的作用  

Role of type I natural killer T cells in the pathogenesis of bronchial asthma

作　　者：何青[1] 聂汉祥[1] 杨巧玉[1] 刘琳琳[1] 刘敏[1] 

机构地区：[1]武汉大学人民医院呼吸内科,430060

出　　处：《国际呼吸杂志》2015年第17期1324-1327,共4页International Journal of Respiration

基　　金：国家自然科学基金（81270076）

摘　　要：支气管哮喘是一种慢性气道炎症性疾病，发病机制尚不完全明确。I型NKT细胞是一种独特的淋巴细胞亚群，通过产生多种细胞因子参与调节免疫反应。近年来I型NKT细胞在支气管哮喘发病机制中的作用备受关注，现就I型NKT细胞在支气管哮喘中的作用及机制作一综述。Bronchial asthma is a chronic airways inflammatory disease,and the pathogenesis is not fully clear. Type I natural killer T cell, a unique subpopulation of T lymphocytes, has been shown to regulate immune responses through a massive production of a various cytokines. The role of type I natural killer T ceils in the pathogenesis of bronchial asthma has received much concern in recent years. Here is a review about the roles and mechanism of type I natural killer T cells in regulating the development of bronchial asthma.

关 键 词：I型NKT细胞 支气管哮喘 气道高反应 TH2反应 

分 类 号：R562.25[医药卫生—呼吸系统]