生长激素替代治疗成人生长激素缺乏症的有效性与安全性  

Effectiveness and safety of growth hormone replacement therapy in adults with growth hormone deficiency

作　　者：林晨红 宋筱筱[1] 徐小红[1] 

机构地区：[1]浙江大学医学院附属第二医院内分泌科,杭州310009

出　　处：《国际内分泌代谢杂志》2015年第5期336-339,共4页International Journal of Endocrinology and Metabolism

基　　金：浙江省科技计划项目（2012C33054）

摘　　要：成人生长激素缺乏症可致机体组分改变、糖、脂代谢紊乱、骨代谢异常、心血管疾病风险增加及生活质量下降等,生长激素替代治疗可有效改善以上情况.但生长激素广泛的生理作用使其安全性备受争议,近几年大部分文献提示生长激素替代治疗不增加糖尿病的发生、肿瘤复发、新发恶性肿瘤及心血管事件等,但仍缺乏大量随机、对照研究,故在生长激素治疗时应严密监测血清胰岛素样生长因子-1水平、血脂、血压、血糖、骨密度、肿瘤标志物及生活质量等指标.Adult growth hormone deficiency causes a series of abnormities including abnormal body composition,impaired glucose and lipid metabolism,abnormal bone metabolism,as well as increased cardiovascular risk and decreased living quality.Growth hormone replacement therapy can effectively improve those abnormalities.However,the safety of growth hormone is controversial since growth hormone has extensively physiological functions.In recent years,most of the studies revealed that the incidence of diabetes mellitus,tumor recurrence,second neoplasms and cardiovascular events in growth hormone replacement therapy did not increase,although large randomized controlled studies are needed to reach the conclusion.Serum insulin-like growth factor-1 level,serum lipids,blood pressure,plasma glucose,bone mineral density,cancer biomarkers and living quality should be closely monitored during the period of growth hormone replacement therapy.

关 键 词：生长激素替代治疗 成人生长激素缺乏症 有效性 安全性 

分 类 号：R587.1[医药卫生—内分泌]