脑梗死患者血尿酸水平与颈动脉粥样硬化的相关性研究  

The study of correlation between serum uric acid level and carotid atherosclerosis in patients with cerebral infarction

作　　者：宋成福[1] 蔡璐[1] 吴丽明[1] 马继明[1] 刘翔宇[1] 金鹿[1] 王敏[1] 

机构地区：[1]同济大学附属上海市杨浦医院老年医学四科,上海200093

出　　处：《中国医刊》2015年第9期33-36,共4页Chinese Journal of Medicine

基　　金：上海市杨浦区2012年度鼎元资金资助项目[(2012)4号];上海市杨浦区卫计委2013年度科研基金资助项目(201303号)

摘　　要：目的探究脑梗死患者血尿酸水平与颈动脉粥样硬化的相关性。方法选取2014年1月到2014年12月期间本院接收治疗的脑梗死患者300例。测定患者的血脂水平和血尿酸水平。使用超声检查检测患者是否有颈动脉斑块,将300例患者分为无斑块组和斑块组,并采用多因素logistic对影响斑块发生的因素进行回归分析。根据斑块的性质,将斑块组患者分为不稳定斑块组和稳定斑块组,对比各组间血尿酸的水平差异。结果无斑块组有137例,斑块组163例,比较两组患者的性别、年龄、总胆固醇、肥胖发生率和血尿酸水平,差异有显著性(P<0.05)。多因素logistic回归分析显示,年龄、性别、血尿酸、肥胖与颈动脉粥样硬化斑块有回归关系。稳定斑块组有88例患者,不稳定斑块组有75例。稳定斑块组、不稳定斑块组、无斑块组的血尿酸水平比较,差异有显著性(P<0.05)。无斑块组和不稳定斑块组的血尿酸相比较,差异有显著性(P<0.05)。结论脑梗死患者的血尿酸水平升高与颈动脉粥样硬化的发生有密切的关系,且与不稳定斑块的关系最密切。高龄、男性、总胆固醇、肥胖和尿酸水平升高是造成颈动脉粥样硬化斑块的危险因素。Objective To explore the correlation between serum uric acid levels and carotid atherosclerosis in patients with cerebral infarction. Method 300 patients with cerebral infarction were selected from our hospital to receive treatment during January 2014 to December 2014. 300 patients blood lipid levels and blood uric acid levels were measured. Ultrasound was used to detect whether patients have carotid plaques, 300 patients were divided into without plaque group and plaque group, and the factors affecting plaque was analyzed by multivariate logistic regression. Depending on the nature of plaque, the plaque group was divided into unstable plaque group and stable plaques, and the differences among the groups in blood levels of uric acid were compared. Result There was a statistically significant difference between no plaque group 137 cases and plaque group 163 cases who were compared with gender, age, total cholesterol（TC）, the incidence of obesity and blood uric acid levels （P〈0.05）. It showed that age, sex, serum uric acid, obesity and carotid atherosclerosis plaque had a regression relationship which analyzed by logistic regression. There were 88 patients in the stable plaque group and 75 cases in the unstable plaque group. There was a significant difference in the level of serum uric acid among stable plaque group, unstable plaque group and non-plaque group （ P〈0.05 ）. There was a significant difference in the serum uric acid between the non-plaque group and the unstable plaque group （ P〈0.05 ）. Conclusion The rise of serum uric acid level in patients with cerebral infarction is closely related to the occurrence of carotid atherosclerosis and unstable plaque is the most closely related. Age, male, total cholesterol, obesity and uric acid levels are the risk factors of carotid atherosclerosis plaque.

关 键 词：脑梗死 血尿酸 颈动脉粥样硬化 

分 类 号：R543[医药卫生—心血管疾病]