5mg唑来膦酸治疗绝经后妇女骨质疏松症不良反应的观察及护理  

Observation and nursing of the adverse effects of 5mg zoledronic acid in the treatment of postmenopausal osteoporosis

作　　者：袁铭绩 黄淑纾[1] 

机构地区：[1]南通大学附属医院,226000

出　　处：《内蒙古中医药》2014年第35期168-170,共3页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:探讨临床应用5mg唑来膦酸治疗绝经后骨质疏松过程中的出现的不良反应,观察综合护理干预能否有效减少不良反应的发生,以及是否能帮助缓解骨质疏松疼痛。方法:将满足入排标准的骨质疏松症患者随机分为观察组和对照组,均接受静脉使用5mg唑来膦酸治疗,其中观察组采用综合护理干预方法,对照组常规进行用药指导,比较两组不良反应的发生情况以及疼痛缓解情况。结果:唑来膦酸用药后的不良反应中,流感样症状、发热以及肾脏事件的发生率在观察组低于对照组,治疗后的疼痛缓解率在观察组较对照组明显,差异均具有统计学意义(P<0.05)。结论:综合护理干预可以减少5mg唑来膦酸在治疗骨质疏松症过程中不良反应的发生,还可有助于疼痛的进一步缓解。Objective To investigate the adverse effects of zoledronic acid in the management of patients with postmenopausal osteoporosis, and to explore whether the comprehensive nursing intervention method can effectively reduce the incidence of adverse effects, while helping relieving the pain of osteoporosis. Methods Patients diagnosed with postmenopausal osteoporosis were randomly assigned to receive either comprehensive nurs- ing intervention method or routine medication guide during the use of IV zoledronic acid 5 mg, adverse effects and pain relief after the adminis- tration were compared between the two groups. Results After the administration of zoledronic acid, the incidence of flu-like symptoms, fever and renal events in the observation group were all less significantly （P〈0.05）than in the control group. Pain relief after treatment in the observation group exceeded remarkably （P〈0.05） which in the control group. Conclusion The comprehensive nursing intervention method can reduce the ad- verse effects after the administration of zoledronie acid, and help relieving pain.

关 键 词：骨质疏松症 唑来膦酸 不良反应 护理 

分 类 号：R473.5[医药卫生—护理学]