TAC及CMF方案治疗晚期乳腺癌术后疗效观察  

作　　者：李兴[1] 邹文凯[1] 杨敏[1] 钱正宇[1] 张涛林[1] 

机构地区：[1]四川成都市中西医结合医院北区普外科,四川成都610017

出　　处：《中文科技期刊数据库（文摘版）医药卫生》2015年第5期16-17,71,共3页

摘　　要：比较乳腺癌患者紫杉醇,阿霉素及环磷酰胺(TAc)与环磷酰胺,甲氨喋呤和氟尿嘧啶(cMF)联合化疗术后疗效观察。方法:收集2005年1月至2009年1月我院收治的经病理组织学证实、有完整随访资料的282例可手术乳腺癌患者的临床资料,其TAC方案164例,CMF方案118例。回顾性分析两组患者复发及生存情况,记录患者不良反应情况,对统计结果进行分析。结果:总体上TAC组患者复发转移率包括肝、肺转移明显低于CMF组患者(P〈0.05),TAC方案组白细胞数、血红蛋白量、尿蛋白、恶心呕吐、口腔溃疡、谷草转氨酶、碱性磷酸酶、心律失常、高血压及低血压发生率高于CMF方案组比较有统计学意义(P〈0.05):两组患者在便秘、腹泻、总胆红素、血小板、出血、尿素氮、肌酐、疼痛脱发抑制程度相比较差异无统计学意义(P〉0.05)。结论:TAC方案化疗的不良反应较CMF方案轻微,在病情允许情况下,可以选择TAC方案,降低患者不良反应,提高生活质量。Objective to compare the breast cancer patients with docetaxel, doxorubicin and cyclophosphamide (TAC) combination chemotherapy with cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy efficacy of postoperative. Methods clinical data collected from January 2005 to January 2009 in our hospital confirmed by histopathology, TAC program 164 cases, CMF program 118 cases.A retrospective analysis of two groups of patients relapse and survival recorded adverse reactions in patients, the statistical analysis of the results.Result Overall recurrence rate in patients with TAC group including liver, lung metastasis was significantly lower than the CMF group of patients (P〈0.05), TAC regimen WBC, HGB, PRO, nausea and vomiting, mouth ulcers, ALT, GGT, arrhythmia, hypertension and high incidence of hypotension in the CMF group program group (P〈0.05) Two groups ofpatients with eonstipation, diarrhea, TBIL, PLT, bleeding, BUN, CR, pain, hair loss, the degreeofinhibition. Conclusion TAC chemotherapy side effects than CMF program slightly, allowing the disease situation, you can choose TAC program, reduce adverse reactions in patients, improving quality of life.

关 键 词：毒性反应 

分 类 号：R2[医药卫生—中医学]