蛇床子素微乳抗炎作用的实验研究  

Experimental Research of Cnidium Lactone Micro- emulsion on the Anti- inflammatory Effect

作　　者：李浩铮 王永辉[1] 房树标[1] 高丽[1] 柴智[1] 周然[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《世界中西医结合杂志》2015年第8期1077-1078,1082,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：山西省科技创新项目(2008101017);山西省科技基础条件平台建设项目(2011091014)

摘　　要：目的观察蛇床子素微乳的抗炎作用。方法采用二甲苯致小鼠耳肿胀、蛋清致大鼠足跖肿胀的实验动物模型,以浓度为2 mg/ml,4 mg/ml,8 mg/ml的蛇床子素微乳局部给药,观察蛇床子素微乳局部外用的抗炎作用。结果蛇床子素微乳各剂量组均有不同程度的抑制二甲苯所致小鼠耳廓肿胀的作用,其中,高剂量组与模型对照组、基质对照组相比较差异有统计学意义(P<0.05);蛇床子素微乳各剂量组均有不同程度的抑制蛋清所致大鼠足廓肿胀的作用,其中,高剂量组与模型对照组、基质对照组相比较,在不同测量时间点均有统计学意义(P<0.05),且与皮炎平组相比较差异无统计学意义(P>0.05)。结论蛇床子素微乳局部外用可显著抑制二甲苯所致小鼠耳廓肿胀和蛋清所致的大鼠足跖肿胀,具有明显的抗炎作用。Objective To observe the anti - inflammatory effect of cnidium lactone micro - emul-sion. Methods Xylene was used to induce auricular swelling in mice and egg white was to induce vola pedis swelling in rats so as to prepare experimental animal models. Cnidium lactone micro - emulsion,2 mg/ ml,4 mg/ ml and 8 mg/ ml was used externally and locally. The anti - inflammatory effect of cnidium lactone micro- emulsion for the local external application was observed. Results Cnidium lactone micro - emulsion of each dose inhibited auricular swelling in mice induced by xylene to different extents,in which,the differences were significant in comparison of the high dose group with the model control group and matrix control group （P ﹤ 0. 05）. Cnidium lactone micro - emulsion of each dose inhibited vola pedis swelling induced by egg white in rats to different extents,in which,the differences were significant in comparison of the high dose group with the model control group and matrix control group at different time points（P ﹤ 0. 05）,and were not significant as compared with the compound dexamthasone acetate cream group（ P 〉 0. 05）. Conclusion Cnidium lactone micro - emulsion for local external application significantly inhibits auricular swelling in-duced by xylene in mice and vola pedis swelling induced by egg white in rats and it presents apparent anti -inflammatory effect.

关 键 词：蛇床子素 微乳 抗炎 

分 类 号：R285.5[医药卫生—中药学]