缺血性心力衰竭患者心房颤动与血清尿酸水平的关联性  

Effect of serum uric acid levels on atrial fibrillation in patients with ischemic heart failure

作　　者：冯天福[1] 赵华云[1] 罗智敏[1] 罗子幸[1] 

机构地区：[1]佛山市中医院内六科,广东佛山528000

出　　处：《心脏杂志》2015年第5期582-584,共3页Chinese Heart Journal

摘　　要：目的探讨缺血性心力衰竭（HF）患者心房颤动（AF）与血清尿酸（SUA）水平的关联性。方法连续性收集于2012年10月~2014年10月就诊于佛山市中医院的缺血性HF患者363例,根据心电图或者病史记录将患者分为AF组和无AF组,比较两组间基线特征及SUA与AF的相关性。结果363例患者中,共有78例患者患有AF,285例患者为正常窦性心律。与无AF患者相比,AF患者的SUA水平显著提高〔（64±21） vs.（57±19） mg/L,P〈0.01〕。同时,AF组患者的年龄更大〔（71±8） vs.（66±11）岁,P〈0.01〕。此外,AF患者的超声心动图指标,包括左室射血分数、左房内径、左心室舒张末期内径以及左心室舒张末期容积,同样显著高于窦性心律正常的患者。多因素回归分析显示,校正相关影响因素后,SUA水平仍为AF的独立相关因素（OR=1.27,95% CI,1.06-1.52,P≤0.01）。结论SUA水平是缺血性HF患者AF的独立相关因素。AIM To investigate the effect of serum uric acid （SUA） levels on atrial fibrillation （AF） in patients with ischemic heart failure （HF）. METHODS A total of 363 consecutive patients with ischemic HF enrolled in our hospital were divided into two groups： AF group and non-AF group. We examined the baseline characteristics between groups and evaluated the relationship between SUA and AF by multivariate logistic regression analysis. RESULTS AF occurred in 21.5% （78/363） patients and 78.5% （285/363） patients had normal sinus rhythm. SUA levels in AF patients were significantly increased compared with those in normal sinus rhythm patients [ （6. 4 ± 2. 09 ） vs. （5.7 ± 1.9 ） mg/dl, P 〈 0. 001 ]. Age in AF patients was significantly higher than in normal sinus rhythm patients [ （71 ± 8 ） vs. （66 ± 11 ） mg/dl, P 〈 0. 01 ]. Echocardiographic parameters including ejection fraction, left atrial diameter, left ventricle end-diastolic diameter and left ventricle end-diastolic volume in AF patients were also significantly higher than those in normal sinus rhythm patients. Multivariate analysis showed that SUA was an independent risk factor of AF in patients with ischemic HF （ OR = 1.27, 95% CI, 1.06 - 1.52, P =0. 010）. CONCLUSION SUA level is significantly higher in AF patients and is independently associated with AF in patients with ischemic HF.

关 键 词：心力衰竭 缺血性 心房颤动 血清尿酸 

分 类 号：R541[医药卫生—心血管疾病]