Transformation optics for efficient calculation of transmembrane voltage induced on cells  

作　　者：廖胤鸿 朱铧丞 唐正明 黄卡玛 

机构地区：[1]School of Electronic Information and Engineering,Sichuan University [2]School of Electronics Information and Engineering China West Normal University

出　　处：《Chinese Physics B》2015年第10期31-35,共5页中国物理B（英文版）

基　　金：Project supported by the National Key Basic Research Program of China(Grant Nos.2013CB328900 and 2013CB328905)

摘　　要：We present a novel efficient approach in calculating induced transmembrane voltage（ITV） on cells based on transformation optics. As cell membrane is much thinner than the dimension of a typical cell, discretizing the membrane needs numerous meshes. Using an anisotropic medium based on transformation optics, the thickness of the membrane can be exaggerated by at least one order, which eliminates rigorous mesh refinement and reduces unknowns greatly. The accuracy and efficiency of the proposed method are verified by a cylindrical cell model. Moreover, the influence on ITV with bound water（BW） layers is also studied. The results show that when cells are exposed to nanosecond electric field, BW layers should be rigorously considered in calculating ITV.We present a novel efficient approach in calculating induced transmembrane voltage（ITV） on cells based on transformation optics. As cell membrane is much thinner than the dimension of a typical cell, discretizing the membrane needs numerous meshes. Using an anisotropic medium based on transformation optics, the thickness of the membrane can be exaggerated by at least one order, which eliminates rigorous mesh refinement and reduces unknowns greatly. The accuracy and efficiency of the proposed method are verified by a cylindrical cell model. Moreover, the influence on ITV with bound water（BW） layers is also studied. The results show that when cells are exposed to nanosecond electric field, BW layers should be rigorously considered in calculating ITV.

关 键 词：efficient calculation transmembrane voltage transformation optics anisotropic medium mem- brane bound water layer 

分 类 号：O484.42[理学—固体物理]