姜黄丸水分含量测定近红外定量模型的建立  

Establishment of quantitative model for determining moisture content in Jiang Huang pills by near infrared spectroscopy

作　　者：张辉[1] 韩红玉[2] 段晓颖[1] 陶明[3] 

机构地区：[1]河南中医学院第一附属医院国家中医药管理局中药制剂三级实验室,河南郑州450000 [2]河南中医学院,河南郑州450008 [3]河南省食品药品检验所,河南郑州450003

出　　处：《中国医院药学杂志》2015年第18期1668-1671,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的：运用近红外光谱（NIR）技术对姜黄丸水分进行快速测定。方法：采集不同批次姜黄丸样品的近红外光谱图,结合OPUS软件进行预处理,在7 552.3-6 707.5 cm^-1,6 699.8-5 538.8 cm^-1,5 515.7-4 204.3 cm^-1谱段内,选择8个主成分,采用偏最小二乘法（PLS）建立姜黄丸水分近红外定量模型。结果：所建模型相关系数（R2）为0.998 6,交互验证均方根偏差（RMSECV）为0.233,仪器精密度及样品重复性良好,所建模型可以准确测出姜黄丸水分含量。结论：该方法具有快速、准确、简便的特点,可以用于大批量姜黄丸水分含量的快速在线检测。OBJECTIVE To mainly study application of near infrared spectroscopy for rapid determination of moisture content in Jiang Huang pills.METHODS Near infrared spectra of Jiang Huang pills of different batches were determined,and pretreated by OPUS.Eight major contents were selected within wavebands of 7 552.3-6 707.5 cm^-1,6 699.8-5 538.8cm^-1 and 5 515.7-4 204.3 cm^-1 to establish near infrared quantitative model with partial least squares（PLS）.RESULTSCorrelation coefficient（R2）of quantitative model of NIR spectroscopy was 0.998 6 for moisture.Root mean square error of cross validation（RMSECV）was 0.233.Meanwhile,NIR instrument had good precision.Samples had great reproducibility.CONCLUSION This method is quick,accurate and simple,and can be applied for rapid online determination of moisture in large quantities of Jiang Huang pills.

关 键 词：近红外光谱法 姜黄丸 水分含量 偏最小二乘法 

分 类 号：R927[医药卫生—药学]