宫颈病变患者HPV-DNA、IL-17检测的临床意义及其相关性  

Clinical significance of detecting HPV-DNA and IL-17 in patients with cervical lesion and their correlation

作　　者：周辉 陈小兰 

机构地区：[1]衢州市柯城区妇幼保健院检验科,浙江衢州324000

出　　处：《中国妇幼健康研究》2015年第4期861-862,共2页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨宫颈病变患者人乳头状瘤病毒DNA(HPV-DNA)、白细胞介素17(IL-17)检测的临床意义及其相关性。方法 2011年5月至2013年5月从衢州市柯城区妇幼保健院收治的宫颈病变患者中随机选择60例检测其宫颈组织中HPVDNA和IL-17含量。结果 60例宫颈病变患者中,HPV呈阴性的患者占41.67%(25/60),阳性占30.00%(18/60),其余28.33%(17/60)为宫颈癌患者,3组构成比无显著性差异(x^2=12.21,P>0.05)。HPV阳性组和宫颈癌组的几.17水平均显著高于阴性组(t=8.11,11.13,P<0.05),阳性组和宫颈癌组比较,无显著性差异(t=2.15,P>0.05。结论 IL-17和宫颈癌的发生发展有一定相关性,临床对宫颈癌进行诊断和治疗以及预后判断时,可以积极的对患者进行高危HPV联合IL-17水平检测。Objective To explore the clinical significance of human papilloma virus DNA （ HPV-DNA ） and interleukin 17 （ IL-17 ） detecting among patients with cervical lesions and their correlation.Methods Sixty cases of cervical lesions were selected from the patients admitted in Maternal and Child Health Hospital of Kecheng District in Quzhou City from May 2011 to May 2013, and HPV-DNA and IL-17 contents of them were detected.Results HPV was negative in 41.67%of patients （25/60）, HPV was positive in 30.00%（18/60）, and the rest were cases of cervical cancer.There was no significant difference in percentage （χ^2 =12.21,P〉0.05）.IL-17 level of HPV positive group and that of cervical cancer group was significantly lower than that of HPV negative group （ t value was 8.11 and 11.13, respectively, both P〈0.05）, but there was no significant difference in the level of IL-17 between HPV positive group and cervical cancer group （ t =2.15, P 〉0.05）.Conclusion There is certain correlation between IL-17 level and the development of cervical cancer. Detecting of high risk HPV combined with IL-17 level could be done actively at diagnosis, treatment and prognosis judgment of cervical cancer.

关 键 词：宫颈病变 人乳头状瘤病毒DNA 白细胞介素17 相关性 

分 类 号：R711.7[医药卫生—妇产科学]