子宫内膜异位症患者卵泡输出率评估卵巢反应性及IVF-ET妊娠结局  

Follicular output rate used for prediction of ovarian response and pregnancy outcome in patients with endometriosis(EMs)undergoing IVF-ET

作　　者：张群芳[1] 陈国勇[1] 黄惠娟[1] 黄润瀚[1] 何凌云[1] 宋岩峰[1] 

机构地区：[1]南京军区福州总医院妇产科生殖中心,350025

出　　处：《中国妇产科临床杂志》2015年第5期406-409,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：南京军区医学科技面上项目(MS125);福州总医院科研课题(201212)

摘　　要：目的通过子宫内膜异位症(EMs)患者卵泡输出率(FORT)评估卵巢反应性及IVF-ET妊娠结局。方法 239例行IVF-ET治疗的EMs不孕患者,分高、低2个FORT组,比较两组间临床和实验室的各项指标。结果两组间年龄、不孕年限、体质指数、基础E2、Gn用量、受精率、卵裂率和移植胚胎数等差异无统计学意义(P>0.05);两组间基础FSH、排卵前卵泡数(PFC)、h CG日E2值、获卵数、优胚率、卵巢过度刺激综合征(OHSS)发生率差异有统计学意义(P<0.05)。高FORT组的种植率[38.75%(31/80)vs26.06%(37/142)]、临床妊娠率[50.67%(38/75)vs32.85%(45/137)]高于低FORT组,但差异无统计学意义(P>0.05)结论高FORT EMs患者有较高的卵巢反应性、胚胎种植率和临床妊娠率。Objective To investigate whether Follicular Output Rate （FORT） is associated with ovarian response and pregnancy outcome for patients with endometriosis （EMs） undergoing in vitro fertilization and embryo transfer （IVF-ET） treatment. Methods 239 infertility women who underwent IVF from January 2012 to November 2013 resctuited in this study. The corresponding FORT value was calculated. 239 EMs infertility women were divided into 2 groups. Low FORT （119 women） and High FORT （120 patients）. Analyzed the relationship between clinical and laboratory data and the response of ovarian and IVF-ET pregnancy outcome. Results There were no significant difference in age, infertility duration, boby mass index （BMI）, bE2, Gn dosage, fertilization rate, cleavage rate and the number of embryo transferred in the two groups （P 〉 0.05）. There were significant difference in the two groups at bFSH, PFC, E2 levels on hCG day, number of retrieved oocytes, good-quality embryos rate and OHSS （ovarian hyperstimulation syndrome） rate （P 〈 0.05）. There was an increasing tendency in implantation rate [38.75% （31/80） vs 26.06% （37/142） ] and clinical pregnancy rate [50.67% （38/75） vs 32.85% （45/137） ] in high FORT group than in low FORT group, but had no significant difference （P 〉 0.05）. Conclusion For patients undergoing IVF-ET treatment, the ovarian response, implantation rate and clinical pregnancy rate were higher in high FORT EMs than that in lower FORT.

关 键 词：子宫内膜异位症 体外受精-胚胎移植 卵泡输出率 卵巢反应性 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]