热休克蛋白免疫增效作用研究进展  

Progress on in Immune Synergistic Effects of Heat Shock Proteins

作　　者：吴燕[1] 王琦[1] 周碧君[1] 石平 黄德江 程振涛[1] 

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025 [2]高峰镇农业服务中心,贵州贵安561108

出　　处：《动物医学进展》2015年第8期82-85,共4页Progress In Veterinary Medicine

基　　金：黔西南州种草养羊产业发展省州科技合作专项项目(黔西南科合[2012]5号);贵州省自然科学技术基金项目(黔科合J字[2011]2332号)

摘　　要：热休克蛋白是生物细胞受到应激原刺激后产生的一类细胞伴侣蛋白,其包括了大分子量HSP家族、HSP90家族、HSP70家族、HSP60家族、小分子量HSP家族和泛素等。其在淋巴细胞和巨噬细胞的活化、抗原经典呈递和交叉呈递途径以及作为佐剂增强抗原的免疫原性,调节机体的免疫应答水平方面发挥了重要作用。在疫苗研究中,热休克蛋白作为免疫佐剂已被证实具有重要的调节作用。论文就热休克蛋白的分类、热休克蛋白作为分子伴侣及其在抗原递呈和诱导免疫应答方面的作用研究进展进行综述,为热休克蛋白的进一步研究提供参考。Heat shock protein is a class of cellular chaperones produced by living cells after stimulation by the stressor,which include high molecular weight HSPs,HSP90 families,HSP70 families,HSP60 fami-lies,small molecular weight HSPs and ubiquitin,etc.It play an important role in the activation of lym-phocytes and macrophages,antigen presentingvia classic and cross-presentation pathways and as an adju-vant to enhance the immunogenicity of antigens,regulate the body's immune response levels.The function of HSPs as immune adjuvant has been confirmed by many researchs.This article summarized the progress on classification,as a molecular chaperone,the active mechanism of antigen presentation and inducing im-mune responses of heat shock proteins in order to provide a theoretical basis for further study of heat shock proteins.

关 键 词：热休克蛋白 免疫增效 作用 

分 类 号：S852.3[农业科学—基础兽医学]