肾脏缺血后处理对缺血再灌注损伤保护作用的研究进展  

Research progress on ischemic post-conditioning for renal ischemia and reperfusion injury

作　　者：王磊[1] 刘修恒[1] 陈晖[1] 

机构地区：[1]武汉大学人民医院泌尿外科,湖北省武汉市430060

出　　处：《职业与健康》2015年第16期2292-2294,2298,共4页Occupation and Health

基　　金：国家自然科学基金(项目编号:30901494)

摘　　要：肾脏缺血再灌注损伤是肾脏移植过程中不可避免的病理生理过程。缺血后处理是在缺血之后、再灌注开始之前,一种短暂连续的缺血、再灌注循环,在动物模型中,肾脏缺血后处理已经证实了其对肾脏缺血再灌注损伤的保护作用。作者综述了肾脏缺血再灌注损伤模型的建立及肾脏缺血后处理对再灌注损伤的相关保护机制。Renal ischemia and reperfusion injury is inevitable in pathological physiological process of kidney transplantation. Ischemic post-conditioning, which is a short and continuous circulation of ischemia and reperfusion, is often performed after ischemia and before the onset of reperfusion period. In animal models, ischemic post-conditioning has already confirmed its protective effects for renal ischemia and reperfusion injury. This paper reviews the establishment of renal ischemia and reperfusion injury model, and the protective mechanism of ischemic post-conditioning for renal isehemia and reperfusion injury.

关 键 词：肾脏 缺血再灌注 缺血后处理 

分 类 号：R181.32[医药卫生—流行病学]