A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena  

作　　者：SUN Jing HUO Hui-Xia HUANG Zheng ZHANG Jing LI Jun TU Peng-Fei 

机构地区：[1]Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine [2]School of Chinese Materia Medica, Beijing University of Chinese Medicine

出　　处：《Chinese Journal of Natural Medicines》2015年第9期699-703,共5页中国天然药物（英文版）

基　　金：supported by the Program for New Century Excellent Talents in University(NCET-13-0693,to LI J);the Project of Standards Improvement of TCM for CP2015(to LI J);TCM support project from Ministry of Industry and Information Technology of China(to LI J.);National Key Technology R&D Program"New Drug Innovation"of China(No.2013ZX 09402201001)

摘　　要：A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringaresinol(2),(+)- lyoniresinol(3), 5,5′-dimethoxy lariciresinol(4),(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde(5), kaempferol-3-O-(2′′,6′′-di-O-p-trans-coumaroyl)-β-glucoside(6), arjunolic acid(7), vanillic acid(8), scoparone(9), and β-sitosterol(10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.A new γ-alkylated-γ-butyrolactone, named melongenolide A（1）, along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A（1）,（＋）-syringaresinol（2）,（＋）- lyoniresinol（3）, 5,5′-dimethoxy lariciresinol（4）,（＋）-（7R,8R）-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde（5）, kaempferol-3-O-（2′′,6′′-di-O-p-trans-coumaroyl）-β-glucoside（6）, arjunolic acid（7）, vanillic acid（8）, scoparone（9）, and β-sitosterol（10）. Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.

关 键 词：Solanaceae Solanum melongena γ-Alkylated-γ-butyrolactone Melongenolide A Anti-inflammation 

分 类 号：R284.1[医药卫生—中药学] R965.1[医药卫生—中医学]