改良大黄承气汤灌肠治疗重型意识障碍的临床研究  

Clinical Study of Modified Dahuangchengqi Decoction Enema for the Treatment of Patients with Severe Coma

作　　者：施宏建[1] 邓洁红[1] 刘宁[1] 

机构地区：[1]四会市中医院急诊科,广东四会526200

出　　处：《中西医结合研究》2015年第4期173-175,共3页Research of Integrated Traditional Chinese and Western Medicine

基　　金：肇庆市科技计划项目(No.2012E312)

摘　　要：目的评价改良大黄承气汤灌肠治疗重型意识障碍患者的效果。方法将重型意识障碍患者300例随机分为对照组及观察组,每组各150例,对照组给予生理盐水灌肠,观察组采用改良大黄承气汤灌肠,比较2组治疗前后白细胞(WBC)、中性粒细胞(NEU)、淋巴细胞(LYM)及C-反应蛋白(CRP)水平,以及意识障碍持续时间、格拉斯哥昏迷评分(GCS)及住院时间的差异。结果治疗后,2组WBC、NEU、LYM及CRP均有不同程度下降,与治疗前比较差异有统计学意义(P<0.05),且观察组WBC、NEU、LYM及CRP均显著低于对照组(P<0.05);观察组患者的意识障碍持续时间及住院时间显著缩短GCS评分显著升高,与对照组比较差异有统计学意义(P<0.05,P<0.01)。结论改良大黄承气汤灌肠治疗重型意识障碍有效。Objective To evaluate the effect of modified Dahuangchengqi decoction enema for the treatment of patients with severe coma. Methods 300 patients with severe coma were randomly divided into the control group and the observation group（n= 150）. Patients in the control group received the saline enema while patients in the observation group received the enema with modified Dahuangchengqi decoction. White blood cell（WBC）, neutrophils（NEU）, lymphocyte（LYM）and C-reactive protein（CRP）levels were examined before and after the treatment. The duration of unconsciousness,Glasgow Coma Scale（GCS） and the length of hospitalization were also compared. Results Compared with the pre-treatment, blood WBC, NEU, LYM and CRP levels were decreased in both groups. Compared with the control group, the above inflammatory markers were significantly reduced in the observation group（P〈0.05）. Moreover, compared with the control group,the duration of unconsciousness and the length of hospitalization were reduced while GCS score were elevated in the observation group （P〈0.05, P〈0.01）. Conclusion Modified Dahuangchengqi decoction is effective in the treatment of severe coma.

关 键 词：意识障碍 中药灌肠 大黄承气汤 炎性物质 

分 类 号：R278[医药卫生—中医学]