类风湿性关节炎患者滑膜组织中HIF-1α与MMPs相关性研究  

Correlation between HIF-1α and MMPs in synovial tissues of patients with rheumatoid arthritis

作　　者：翟天航 张洁[1] 李会丹[1] 火蓉芬[1] 沈佰华[1] 李宁丽[1] 

机构地区：[1]上海市免疫学研究所,上海200025

出　　处：《上海交通大学学报（医学版）》2015年第9期1248-1251,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81172856);上海市科委基金(12JC1407700;12401903702)~~

摘　　要：目的探讨类风湿性关节炎(RA)患者滑膜组织中缺氧诱导因子-1α(HIF-1α)的表达与基质金属蛋白酶家族成员(MMPs)表达的相关性。方法利用real-time PCR方法检测RA和骨关节炎(OA)患者滑膜组织中HIF-1α和MMPs的表达并进行相关性分析。结果 RA滑膜组织中HIF-1α、MMP-1、MMP-3、MMP-9与MMP-13 mRNA表达量显著高于OA对照组,且RA滑膜组织中高表达的HIF-1α与MMP-9呈显著的正相关。结论 RA滑膜组织中高表达的HIF-1α可能参与调控MMP-9的表达,参与RA的病理变化进程。Objective To investigate the correlation between the expression of hypoxia-inducible factor-1α（HIF-1α） and the expression of matrix metalloproteinases（MMPs） in synovial tissues of patients with rheumatoid arthritis（RA）.Methods The expressions of HIF-1α and MMPs in synovial tissues of patients with RA and osteoarthritis（OA） were detected by real-time PC R and the correlation analysis was conducted.Results The mRNA expressions of HIF-1α,MMP-1,MMP-3,MMP-9,and MMP-13 in synovial tissues of patients with RA were significantly higher than those of patients with OA.Highly expressed HIF-1α in synovial tissues of patients with RA significantly and positively correlated with MMP-9.Conclusion Highly expressed HIF-1α in synovial tissues of patients with RA may involve in the regulation of the expression of MMP-9 and the process of pathological change of RA.

关 键 词：类风湿性关节炎 缺氧诱导因子-1Α 基质金属蛋白酶 

分 类 号：R593.22[医药卫生—内科学]