幽门螺杆菌感染及炎症因子与动脉粥样硬化性脑梗死的关系  

Relationship between Helicobacter pylori infection and inflammatory factors and atherosclerotic cerebral infarction

作　　者：李秀娟[1,2] 胡东辉 陈辉[1,2] 

机构地区：[1]武汉市中西医结合医院 [2]武汉市第一医院老年病科,湖北武汉430022 [3]湖北省中山医院肝病科,湖北武汉430033

出　　处：《中华医院感染学杂志》2015年第18期4136-4137,4146,共3页Chinese Journal of Nosocomiology

基　　金：湖北省科技攻关基金资助项目(2010AA202A05)

摘　　要：目的探究幽门螺杆菌感染及炎症因子与动脉粥样硬化性脑梗死及腔隙性脑梗死的关系,为临床治疗提供依据。方法选取2011年11月-2014年4月医院收治的动脉粥样硬化脑梗死(Ⅰ组)、腔隙性脑梗死(Ⅱ组)以及身体状况健康的正常人群(Ⅲ组)各120例;使用酶联免疫吸附法(ELISA)对3组患者的血清白细胞介素-8(IL-8)、C-反应蛋白(CRP)以及幽门螺杆菌抗体进行检测,并对结果进行分析;采用SPSS13.0软件进行统计分析。结果Ⅰ组患者HP感染率显著高于其他两组,差异有统计学意义(P<0.05);Ⅰ组患者的IL-8及CRP均高于其他两组,差异有统计学意义(P<0.05);Hp与动脉粥样硬化性脑梗死呈正相关(r=0.610,P<0.05),与腔隙性脑梗死无相关性(r=0.24,P>0.05),患者患有动脉粥样硬化脑梗死后,其体内的IL-8、CRP的含量均明显的升高,与这两者呈正相关(r=0.583、r=0.621,P<0.01)。结论动脉粥样硬化脑梗死的发病与幽门螺杆菌是否感染有关,患者患有动脉粥样硬化脑梗死后,其体内的IL-8与CRP的含量均有明显的升高。OBJECTIVE To explore the relationship between the Helicobacter pylori infection and inflammatory factors and atherosclerotic cerebral infarction and lacunar cerebral infarction so as to provide guidance for clinical treatment.METHODS Totally 120 patients with atherosclerotic cerebral infarction（the groupⅠ）and 120 patients with lacunar cerebral infarction（the groupⅡ）who were treated in the hospitals from Nov 2011 to Apr 2014 were enrolled in the study,and 120 healthy people（the group Ⅲ）were included as well.The serum interleukin-8（IL-8）,C-reactive protein（CRP）,and H.pylori antibodies of the three groups were detected by using enzyme linked immunosorbent assay（ELISA）,the results were analyzed,and the statistical analysis was performed with the use of SPSS13.0software.RESULTS The incidence of the H.pylori infection of the groupⅠ was significantly higher than that of other two groups（P〈0.05）.The levels of IL-8and CRP of the group Ⅰ were significently higher than those of other two groups（P〈0.05）.The H.pylori was positively correlated with the atherosclerotic cerebral infarction（r=0.610,P〈0.05）,but was not correlated with the lacunar cerebral infarction（r=0.24,P〉0.05）.The contents of IL-8 and CRP of the patients were significantly elevated after they had the atherosclerotic cerebral infarction,which was positively correlated with the two（r=0.583,r=0.621,P〈0.01）.CONCLUSION The onset of the atherosclerotic cerebral infarction is associated with the H.pylori infection.The contents of IL-8and CRP of the patients are significantly elevated after they have the atherosclerotic cerebral infarction.

关 键 词：幽门螺杆菌 白细胞介素-8 动脉粥样硬化 腔隙性脑梗死 

分 类 号：R378[医药卫生—病原生物学]