孕期人乳头状瘤病毒感染类型与母婴传播的前瞻性研究  

Prospective study of human papillomavirus infection during pregnancy and mother-to-infant transmission

作　　者：缪剑霞[1] 陈志芳[1] 孙晓琴[1] 

机构地区：[1]南通市妇幼保健院产科,江苏南通226018

出　　处：《中华医院感染学杂志》2015年第18期4276-4278,共3页Chinese Journal of Nosocomiology

基　　金：江苏省科技厅研究基金资助项目(JS2013-08934)

摘　　要：目的探讨人乳头状瘤病毒（HPV）感染类型及母婴传播率,指导临床预防感染。方法回顾性分析2012年1月-2014年1月产前检查HPV的2 132例孕妇临床资料,根据孕妇及新生婴儿的资料及快速核酸分子导流法检测人乳头瘤病毒分型,分析孕期HPV感染分型、母婴传播率。结果 2 132例孕妇中HPV感染280例,感染率为13.13%;年龄〈22、22-24、25-27、28-30、31-33岁及≥34岁的孕妇感染率分别为8.89%、10.17%、12.68%、13.32%、13.88%、16.09%;感染孕妇中HPV高危型251例占89.64%,其中16、52、58型的孕妇分别为51、48、33例,其他高危型119例;HPV低危型孕妇29例;280例HPV感染孕妇产的新生儿中,HPV感染的新生儿63例,母婴垂直传播率22.5%;新生儿HPV高危型54例、低危型9例,分别占85.71%、14.29%;280例HPV感染孕妇中,经阴道产新生儿143例,33例有HPV感染,感染率23.08%;经剖宫产新生儿137例,30例有HPV感染,感染率21.09%。结论孕妇HPV感染率与年龄无显著相关性,孕期感染的HPV多为高危型,新生儿与孕妇感染的HPV分型较为一致,但母婴垂直传播与分娩方式无相关性,孕期HPV的筛查对于预防宫颈癌等恶性病变,以及尽早发现新生儿HPV感染有重要意义,值得临床推广应用。OBJECTIVE To investigate the types of human papillomavirus（HPV）infection and the rate of motherto-infant transmission so as to provide guidance for clinical prevention of the infections.METHODS The clinical data of 2 132 pregnant women who underwent the prenatal examination of HPV from Jan 2012 to Jan 2014 were retrospectively analyzed.The genotypes of HPV were detected based on the data of the pregnant women and neonates as well as rapid nucleic acid molecule diversion method so as to observe the types of HPV infection and the rate of mother-to-infant transmission.RESULTS Of the 2 132 pregnant women,280 had the HPV infection,with the infection rate of 13.13%.The infection rate was 8.89%in the pregnant women aged less than 22 years old,10.17%in those aged between 22 and 24years,12.68%in those aged between 25 and 27years,13.32%in those aged between 28 and 30years,13.88%in those aged between 31 and 33year,16.09%in those aged no less than 34 years old.Of totally 251（89.64%）pregnant women with high risk HPV infection,51 had HPV16infection,48 had HPV52infection,58 had HPV infection,and 119 had other high risk HPV infection.Totally 29 pregnant women had low risk HPV infection.Of the neonates whom were gave birth by 280 pregnant women with HPV infection,63 had HPV infection,and the rate of mother-to-infant vertical transmission was 22.5%;totally 54 neonates had the high risk HPV infection,accounting for 85.71%,and 9neonates had the low risk HPV infection,accounting for 14.29%.Of the 280 pregnant women with HPV infection,143 gave vaginal birth,and 33 neonates had HPV infection,with the infection rate of 23.08%;totally 137 underwent the cesarean section,and 30 neonates had HPV infection,with the infection rate of 21.09%.CONCLUSIONThe incidence of HPV infection in the pregnant women is not significantly associated with the age,and the high risk HPV infection is dominant during the pregnancy.The genotypes of HPV causing infection in the neonates are basically consistent with those in the pregnant women,however,the m

关 键 词：人乳头状瘤病毒 分型 母婴垂直传播 孕期 

分 类 号：R181.32[医药卫生—流行病学]