脑死亡供体肝脏质量影响因素  

Risk factors for liver quality in donation after brain death

作　　者：范林[1] 李弦[1] 张秋艳[1] 叶啟发[1] 

机构地区：[1]武汉大学中南医院武汉大学肝胆疾病研究院武汉大学移植医学中心移植医学技术湖北省重点实验室,430071

出　　处：《中华肝胆外科杂志》2015年第9期637-641,共5页Chinese Journal of Hepatobiliary Surgery

摘　　要：肝移植作为治疗终末期肝病的唯一有效手段，其临床应用已逾半个世纪，而供肝来源的短缺一直是限制其发展的瓶颈。在为数不多的供肝中，如何确定其质量以保证移植患者的预后为目前研究的主要方向。脑死亡造成的全身脏器病理生理改变亦包括肝脏。为此，如何进行相关病理学及血清学检查以确定肝脏使用的安全性十分重要。本文对近年发表的相关文献进行综合、分析，对供体器官质量评价指标进行综述。以期对捐献供体肝脏进行有效评价以利于临床工作。Liver transplantation, a unique effective treatment for end-stage liver diseases, has already been applied in clinical practice for more than half a century. But the shortage of donor liver source has been the bottleneck limiting its develop- ment. How to determine the tiny minority donor liver quality to guarantee the prognosis of transplant patients becomes a hot fo- cus for current research. Brain death causes patho-physiological changes of body organs, including liver. How to carry out rela- ted pathological and serologic tests to determine the safety of the donor liver is a very important issue. In this paper, the articles published in recent years were overviewed and analyzed to sum- marize the evaluation index of donating organ quality. We hope this paper may benefit the treatment through ensuring an effec- tive evaluation on the donor liver in the future.

关 键 词：脑死亡供体 肝移植 影响因素 

分 类 号：R4[医药卫生—临床医学]