脑复聪方治疗肾虚血瘀型轻度认知功能障碍患者16例临床观察  

Clinical Observation on 16 Cases of Mild Cognitive Impairment with the Syndrome of Kidney Deficiency and Blood Stasis Treated with Naofucong Decoction (脑复聪方)

作　　者：崔雅忠[1] 李伏容 张孟仁[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院 [2]北京市西城区金融街社区卫生服务中心

出　　处：《中医杂志》2015年第18期1577-1580,共4页Journal of Traditional Chinese Medicine

摘　　要：目的观察脑复聪方治疗肾虚血瘀型轻度认知功能障碍的临床疗效。方法轻度认知功能障碍肾虚血瘀型患者32例随机分为治疗组和对照组各16例。治疗组给予脑复聪方,每日1剂;对照组给予尼莫地平片10 mg,每日3次口服,两组疗程均为3个月。治疗前后采用韦氏成人智力量表进行词汇、数字广度、算术、数字符号、积木构图评分判定学习记忆功能,同时进行物体记忆测验、快速词汇测验和简易精神状态检查(MMSE)。结果治疗组治疗后词汇、数字广度、算术、积木构图、物体记忆、MMSE评分较治疗前明显提高(P<0.05);数字符号及快速词汇差异无统计学意义(P>0.05)。对照组治疗后物体记忆和MMSE评分较治疗前明显提高(P<0.05),而其余指标差异无统计学意义(P>0.05)。治疗组患者词汇、算术、积木构图治疗前后差值与对照组比较差异有统计学意义(P<0.05)。结论脑复聪方能够改善轻度认知功能障碍患者学习记忆功能和精神状态。Objective To observe the clinical curative effect of Naofucong Decoction in treating patients with mild cognitive impairment with the syndrome of kidney deficiency and blood stasis. Methods Thirty-two patients with mild cognitive impairment with the syndrome of kidney deficiency and blood stasis were randomly divided into treatment group and control group,with 16 cases in each group. The treatment group was given Naofucong Decoction,one dose daily; the control group was given nimodipine tablets 10 mg,3 times a day orally,the treat course of the two groups were 3 months. Before and after treatment,the patients would be scored to determine the learning and memory function by Wechsler Adult Intelligence Scale table on vocabulary,digit span,arithmetic,digit symbol,and blocks composition. At the same time,the object memory test,rapid vocabulary test and simple mental state examination（ MMSE） were carried out. Results After treatment,the vocabulary,digit span,arithmetic,blocks composition,object memory and MMSE score were significantly improved（ P 〈0. 05）,but there was no significant difference in digit symbol and rapid vocabulary（ P〉 0. 05） in the treatment group. The object memory and MMSE score were significantly improved after treatment（ P〈 0. 05）,while the changes of other indexes were not statistically significant（ P 〉0. 05） in the control group. The differences in vocabulary,arithmetic and building blocks between before and after treatment in the treatment group were significantly different from those in the control group（ P 〈0. 05）.Conclusion Naofucong Decoction can improve the function of learning and memory,as well as the mental state of patients with mild cognitive impairment.

关 键 词：轻度认知功能障碍 脑复聪方 神经精神量表 

分 类 号：R277.7[医药卫生—中医学]