氨基葡萄糖治疗亚洲人群骨关节炎的Meta分析  

A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population

作　　者：陈世菊[1] 刘源[1] 石桂秀[1] 

机构地区：[1]厦门大学附属第一医院风湿免疫科,福建厦门361003

出　　处：《华西医学》2015年第9期1627-1632,共6页West China Medical Journal

基　　金：国家自然科学基金(81273285);国家重点基础研究发展计划(973计划)(2014CB541903)~~

摘　　要：目的评价氨基葡萄糖在亚洲人群骨关节炎(OA)患者中的疗效及安全性。方法计算机检索Cochrane图书馆、Pub Med(1950年5月-2014年5月)、Embase(1980年5月-2014年5月)、中国知网中国期刊全文数据库(1978年5月-2014年5月)、(1979年5月-2014年5月)、万方数据库(1990年1月-2014年5月)、维普数据库(1989年5月-2014年5月),收集氨基葡萄糖单用或联合非甾体抗炎药(NSAID)对比仅用NSAID治疗OA的随机对照试验,由2名研究者根据纳入与排除标准筛选文献、提取资料并评价质量后,采用Rev Man 5.1软件进行Meta分析。结果共纳入17个研究,共计2 251例OA患者。Meta分析结果显示:单用氨基葡萄糖总有效率高于NSAID,差异有统计学意义[OR=3.03,95%CI(1.78,5.18),P<0.000 1];氨基葡萄糖联合NSAID与单用NSAID比较,前者总有效率高于后者,差异有统计学意义[OR=4.30,95%CI(1.84,10.06),P=0.000 8]。单用氨基葡萄糖不良事件发生率低于NSAID,差异有统计学意义[OR=0.23,95%CI(0.14,0.37),P<0.000 01];氨基葡萄糖联合NSAID不良事件发生率与NSAID比较差异无统计学意义[OR=0.84,95%CI(0.50,1.41),P=0.50]。结论氨基葡萄糖相较于NSAID,能有效并安全地用于亚洲人群OA的治疗。Objective To study the effectiveness and safety of glucosamine for osteoarthritis （OA） in Asian population. Methods Databases of PubMed, Embase, CNKI, VIP and Wanfang were searched from the time of establishment till May 2014 and controlled trials of glucosamine compared with placebo or nonsteroidal anti- inflammatory drugs （NSAIDs） were included. Quality evaluation and Meta-analysis by using RevMan 5.1 were performed. Results A total of 17 studies including 2 251 cases were included. The efficiency rate in the glucosamine group was higher than that in the NSAIDs group [OR=3.03, 95% CI （1.78, 5.18）, P 〈 0.000 1]. The efficiency rate in the glucosamine combined NSAIDs group was higher than that in the NSAIDs group [OR=4.30, 95%CI （1.84, 10.06）, P=0.000 8]. The safety analysis showed that the adverse event rate in the glucosamine group was lower than that in the NSAIDs group [OR=0.23, 95%CI （0.14, 0.37）, P 〈 0.000 01], while the difference between the glucosamine combined NSAIDs group and the NSAIDs group was not statistically significant [OR=0.84, 95%CI （0.50, 1.41）, P=0.50]. Conclusion Compared with NSAIDs, glucosamine is better and safer for OA treatment in Asian population.

关 键 词：骨关节炎 氨基葡萄糖 亚洲人群 META 分析 

分 类 号：R684.3[医药卫生—骨科学]