HLA-DR4分子与抗类风湿性免疫活性肽构效关系的研究进展  

Research Progress on the Relationship between HLA-DR4Molecule and Immunoactive Peptide of Anti-rheumatoid

作　　者：吕翠翠[1] 曹慧[1] 徐斐[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《天然产物研究与开发》2015年第9期1674-1678,共5页Natural Product Research and Development

基　　金：国家"863"计划(2013AA102207);国家自然科学基金(31201421)

摘　　要：类风湿性关节炎(rheumatoid arthritis,RA)是一种自身免疫疾病,它和人类主要组织相容性复合体(Major Histocompatibility Complex,MHC)的特异性表达有密切关系。其致病机理是MHC分子通过呈递內源或外源免疫活性肽,激活T淋巴细胞,从而引发关节滑膜炎症。研究发现,口服免疫活性肽可以降低RA的致病性,但其机制仍不清楚。因而本文从Anti Jen和相关数据库查阅了和RA相关的免疫活性肽,并结合免疫活性肽的氨基酸组成、带电性等性质深入研究其与MHC分子的构效关系。Rheumatoid arthritis （RA） is a common autoimmune disease and its pathogenesis is strongly associated with the expression of specific MHC （ Major Histocompatihility Complex） molecules. It has been proposed that MHC molecule play a role in RA through presenting endogenous or exogenous peptides to T cells, and then these cells were activated, re- sttlting in the an inflammation of synovium. Recently, immunoaefive peptides are found to be a clinically effective treat- merit for RA, although the underlying mechanisms for this have not been fully studied. Therefore, this study obtained the information of RA immunity peptides from AntiJen and relevant database. Considering their amino acid composition, elec- tile charges and structural properties ,we further explored the relationship between RA immunity peptide and MHC mole- cules

关 键 词：HLA-DR4分子 类风湿性关节炎 构效关系 免疫活性肽 

分 类 号：Q7[生物学—分子生物学]