一清胶囊抗甲型H1N1流感病毒作用  

Anti-virus Effect of Yiqing Capsule on Influenza A Subtype H1N1

作　　者：徐雄良[1] 岳韵 刘小均[1] 杨刚[1] 刘浪[1] 柯潇[1] 郑强[1] 

机构地区：[1]成都康弘药业集团股份有限公司国家企业技术中心,成都610036

出　　处：《中国现代应用药学》2015年第9期1056-1058,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究一清胶囊抗甲型H1N1流感病毒作用。方法采用小鼠气管内注入甲型流感病毒鼠肺适应株A/PR/8/34（H1N1）病毒液建立病毒感染小鼠模型,以肺指数、肺指数抑制率、小鼠累积死亡率为指标,评价一清胶囊体内抗甲型H1N1流感病毒作用。结果 7.3 g·kg^-1一清胶囊（原生药）可降低病毒感染小鼠的肺脏指数（P〈0.05）和小鼠感染病毒后7~9 d内的死亡率（P〈0.01）。结论一清胶囊具有明显的抗甲型H1N1流感病毒作用。OBJECTIVE To evaluate the antivirus effect of Yiqing capsule. METHODS Antivirus test in vivo of Yiqing capsule was carried out by intratracheal injection of influenza A strains A/PR/8/34（H1N1） strain in mice. The lung index, inhibition rate of lung index and death rate of mice were measured to observe the effect of anti-influenza A virus subtype H1N1 in vivo. RESULTS The 7.3 g·kg^-1 Yiqing capsule（crude） could significantly decrease the lung index of viral infected mice（P〈0.05） and the mortality of 7？9 d in viral infected mice（P〈0.01）. CONCLUSION Yiqing capsule has good effect of anti-influenza A virus subtype H1N1 in vivo.

关 键 词：一清胶囊 抗病毒 甲型H1N1流感病毒 

分 类 号：R965.2[医药卫生—药理学]