利拉萘酯喷雾剂的经皮渗透研究  

Study on the Percutaneous Permeability of Liranaftate Spray

作　　者：何敏[1,2] 单瑞平 傅旭春[4] 

机构地区：[1]浙江大学药学院,杭州310058 [2]艾康生物技术(杭州)有限公司,杭州310013 [3]浙江万晟药业有限(公司),杭州310013 [4]浙江大学城市学院药物研究所,杭州310015

出　　处：《中国现代应用药学》2015年第9期1106-1109,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究利拉萘酯喷雾剂的经皮渗透性。方法采用改良Franz扩散池,以小型猪皮肤为渗透屏障,高效液相色谱法测定利拉萘酯含量。结果利拉萘酯喷雾剂和乳膏剂的稳态透皮速率分别为(0.017±0.006),(0.014±0.003)μg·cm?2·h?1;利拉萘酯喷雾剂和乳膏剂的24 h累积渗透量分别为(0.60±0.23),(0.44±0.15)μg·cm?2;利拉萘酯喷雾剂和乳膏剂在皮肤中的药物残留量分别为(8.2±1.3),(7.7±1.6)μg·g?1。结论利拉萘酯喷雾剂的稳态透皮速率、24 h累积渗透量、在皮肤中的药物残留量均稍大于利拉萘酯乳膏剂,但2种剂型之间没有显著性差异。OBJECTIVE To investigate the percutaneous permeability of liranaftate spray. METHODS The improved Franz diffusion cells and the skin of Bama miniature pig were used to investigate the percutaneous permeability of liranaftate. The content of liranaftate was determined by HPLC. RESULTS The steady penetration rate of spray and cream was（0.017±0.006）,（0.014±0.003）μg·cm^-2·h^-1, respectively. The 24 h cumulative permeation quantity of spray and cream was（0.60±0.23）,（0.44±0.15）μg·cm^-2, respectively. The residue in skin of spray and cream was（8.2±1.3）,（7.7±1.6）μg·g^-1, respectively. CONCLUSION Although liranaftate spray shows slightly higher steady penetration rate, 24 h cumulative permeation quantity, and residue than liranaftate cream, there is no significant difference of the steady penetration rate, 24 h cumulative permeation quantity and residue between liranaftate spray and liranaftate cream.

关 键 词：利拉萘酯 喷雾剂 乳膏剂 经皮渗透 

分 类 号：R944[医药卫生—药剂学]