主要禽源病毒相关microRNA的研究进展  

Progress in microRNAs associated with major avian viruses

作　　者：满朝来[1] 穆卫涛[1] 赵冬雪[1] 常杨[1] 

机构地区：[1]哈尔滨师范大学生命科学与技术学院,黑龙江哈尔滨150025

出　　处：《生物工程学报》2015年第9期1289-1300,共12页Chinese Journal of Biotechnology

基　　金：黑龙江省自然科学基金(No.C201135);哈尔滨师范大学科技发展预研项目(No.12XYG-08)资助~~

摘　　要：近年来,禽类病毒性疾病已经成为研究病毒感染和致病机制的重要模型之一,而且病毒与micro RNA的调控关系和机制研究也成为人们关注的焦点。本文简要总结禽源疱疹病毒编码micro RNA的概况,以及禽源疱疹病毒的致瘤性与micro RNA的表达调控关系,同时探讨了利用micro RNA靶向调控机制在病毒疾病(如传染性法氏囊病毒、禽白血病病毒、禽流感病毒等)防治中的可能应用。Recently, avian viral diseases have become one of the main models to study mechanisms of viral infections and pathogenesis. The study of regulatory relationships and mechanisms between viruses and microRNAs has also become the focus. In this review, we briefly summarize the general situations of microRNAs encoded by avian herpesviruses. Also, we analyze the regulatory relationships between tumorigenicity of avian herpesviruses and microRNAs. Additionally, the possible applications for prevention and treatment of viral diseases （such as infectious bursal disease, avian influenza and avian leucosis） using the regulatory mechanisms of microRNAs are also discussed.

关 键 词：鸡 病毒 MICRO RNA 肿瘤 马立克氏病毒 

分 类 号：S852.65[农业科学—基础兽医学]