输入性恶性疟疾病例分析  

Epidemiological and Clinical Analysis of Two Cases of Imported Pernicious Malaria

作　　者：高歌[1] 胡颖新[1] 付婷霞[1] 

机构地区：[1]山东省医学科学院,山东省寄生虫病防治研究所,山东济宁272100

出　　处：《寄生虫病与感染性疾病》2015年第3期120-122,共3页Parasitoses and Infectious Diseases

基　　金：中国全球基金疟疾项目实施性研究专项(No.201201055)

摘　　要：目的探讨山东省非洲输入性恶性疟的流行病学和临床特征及早期诊断、治疗的方法。方法回顾性分析山东省寄生虫病防治研究所2013-2014年收治的2例输入性恶性疟疾患者的流行病学资料特征、临床表现、实验室检查、诊治情况及预后判断。结果临床确诊的2例输入性恶性疟疾患者均有蚊虫叮咬史,均有发热、贫血、血小板减少、肝功能损害。1例发生死亡,1例经抗疟治疗后治愈出院。结论输入性恶性疟患者临床表现复杂,早期进行外周血涂片检查,及时诊断、合理的处理是治疗输入性恶性疟疾的关键。蒿甲醚联合伯氨喹对输入性恶性疟疾有显著的临床疗效,可避免凶险性疟疾的发生。Objective To explore the epidemiological and clinical features, early diagnosis and treatment of Af- rica imported pernicious malaria in Shandong province. Methods Two cases of imported pernicious malaria patients admitted in Shandong Institute of Parasitic Disease Control and Prevention from February 2011 to May 2012 were retrospectively analyzed, including aspects of the epidemiologica] and clinical features, laboratory examination and treatment measures. Results The two cases of imported pernicious malaria patients had a his- tory of mosquito bites, and were manifested fever, anemia, thrombocytopenia, and liver function impairment. One case died and the other was cured after antimalarial treatment. Conclusion The clinical manifestations of imported pernicious malaria are complex, early peripheral blood smear, prompt diagnosis and reasonable treatment are the key measures in treating imported pernicious malaria. The clinical efficacy of artemether combined with primaquine have significant clinical effectiveness in treating falciparum malaria and can avoid the malaria disaster.

关 键 词：恶性疟原虫 输入性 流行病学 临床分析 

分 类 号：R531.3[医药卫生—内科学]