中药保留灌肠在重症胰腺炎急性期的临床研究  

Clinical study of traditional Chinese medicine retention enema in the treatment of acute severe pancreas

作　　者：沈剑彬[1] 王宗立[1] 

机构地区：[1]湖州市第一人民医院普外科,浙江湖州313000

出　　处：《中国临床药理学杂志》2015年第18期1831-1833,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价中药保留灌肠在重症胰腺炎急性期治疗中的临床疗效与安全性。方法入选62例重症胰腺炎患者,随机分为试验组和对照组,各31例,对照组进行常规治疗,试验组在对照组基础上急性期辅以中药保留灌肠治疗,每天一剂,分两次,每次100 m L,10 d为1个疗程。比较2组临床症状(腹痛、腹胀缓解时间,排便恢复时间)、炎性因子(肿瘤坏死因子α、内毒素)、住院时间和治疗效果。结果试验组有效率为93.55%,明显高于对照组的74.19%(P<0.05)。试验组腹痛、腹胀缓解时间和排便恢复时间、住院时间、肿瘤坏死因子α、内毒素、并发症和死亡率明显低于对照组(P<0.05)。结论中药保留灌肠有助于改善急性重症胰腺炎临床症状,减轻炎性因子表达,提高治疗效果。Objective To investigated clinical effect and safety of tradi- tional Chinese medicine （TCM） retention enema in the treatment of acute severe pancreas. Methods A total of 62 cases of severe acute pancreatitis patients enrolled for the study were randomly divided into experiment group and control group, 31 patients in the control group received conventional treatment, patients in experiment group received the TCM retention enema on the basis of the conventional treatment, one dose a day, twice per 100 mL, 10 d course of treatment. Clinical symptoms （abdominal bloating relief time, bowel recovery time ）, inflammatory factors（TNF -α, LPS） , a therapeutic effect of the two groups were com- pared. Results The efficacy of experiment group was 93.55% , significantly higher than that of control group with efficacy 74. 19% （P 〈 0.05 ）. Abdominal pain time, time to ease bloating, and bowel recovery time, hospital stay, TNF - α, endotoxin （ LPS）, complications and mortality of experiment group were significantly lower than those of the control group （ P 〈 0. 05 ）. Conclusion TCM retention enema is helpful to improve the clinical symptoms, reduce inflammatory factor expression and improve the effect of treatment.

关 键 词：清胰承气汤 保留灌肠 重症胰腺炎 炎性因子 

分 类 号：R283[医药卫生—中药学] R657.51[医药卫生—中医学]