心肌缺血再灌注与线粒体功能障碍研究进展  

Effects on mitochondrial dysfunction in myocardial ischemia reperfusion

作　　者：陈景瑞[1] 魏静[1] 施洋[1] 樊官伟[1] 

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《中国临床药理学杂志》2015年第18期1886-1888,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家重点基础研究发展计划(973计划)基金资助项目(2012CB518404);国家自然科学基金资助项目(81273891)

摘　　要：线粒体是机体能量代谢与细胞信号转过程中关键的细胞器,在多种信号传导、调节Ca2+稳态和介导细胞凋亡等过程中均发挥着重要的作用。线粒体功能障碍与扩张型心肌病、缺血再灌注损伤和心力衰竭等心血管疾病的发生发展密切相关。本文围绕缺血再灌注损伤机制与线粒体结构和功能障碍的关系做一简要综述。Mitochondria are critical organelles of energy metabolism in organism and play a pivotal role in, cell signaling process, such as signal transduction, Ca2＋ homeostasis, and apoptotic regulation and other processes. More and more studies show that the development of the dila- ted cardiomyopathy, ischemia -reperfusion injury, the heart failure and other cardiovascular diseases, all of which are also closely related to the mitochondrial dysfunction. This review focuses on the relationship between ischemia - reperfusion injury mechanisms and mitochomlrial dysfunction to make a brief overview.

关 键 词：心肌细胞 缺血再灌注损伤 线粒体 

分 类 号：R318.03[医药卫生—生物医学工程] R541.8[医药卫生—基础医学]