炮制对决明子中萘并吡喃酮苷及蒽醌苷元类成分含量的影响  

Effect of Processing on Naphthopyrone Glycosides and Anthraquinone Aglycone in Semen Cassiae

作　　者：唐力英[1] 徐义龙 周喜丹 周国洪[1] 寇真真[1] 王婷[1] 王祝举[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2015年第18期69-72,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(81173552)

摘　　要：目的:比较炮制对决明子中主要活性成分萘并吡喃酮苷和蒽醌苷元类成分的影响。方法:采用高效液相色谱法检测决明子中3个萘并吡喃酮苷和3个蒽醌苷元的含量,并比较其炮制前后的含量变化。结果:炮制后决明子中3种萘并吡喃酮苷类成分含量均有明显下降,其中红镰霉素龙胆二糖苷下降约21%,决明子苷下降约60%,决明子苷C下降约87%;3种蒽醌苷元变化情况为,橙黄决明素和甲基钝叶决明素的含量变化没有显著性差异,钝叶素的含量升高48%。结论:炮制对决明子主要活性成分萘并吡喃酮苷和蒽醌苷元类的含量均会产生显著影响,其中炮制后萘并吡喃酮苷类成分整体下降,蒽醌苷元类成分有部分含量升高。Objective： To compare the effect of processing on naphthopyrone glycosides and anthraquinone aglycones in Semen Cassiae. Method： The high-performance liquid chromatographic method was used to determine the content of three naphthopyrone glycosides and three anthraquinone aglycones in Semen Cassiae and compare the changes in the content before and after processing. Result： The content of three naphthopyrone glycosides significantly decreased after processing. Specifically, rubrofusaringentiobioside dropped about 21% , cassiaside decreased by 60% , cassiaside C decreased by 87%. As for the changes in the content of the three anthraquinones, there was no significant difference between aurantio-obtusin and chryso-obtusin, but obtusifolin increased by 48%. Conclusion： Processing has a significant effect on the content of naphthopyrone glycosides and anthraquinone aglycones in Semen Cassiae. Specifically, naphthopyrone glycosides in Semen Cassiae decreased integrally, whole anthraquinone aglycones increased partially after processing.

关 键 词：决明子 炮制 萘并吡喃酮苷 蒽醌苷元 含量变化 

分 类 号：R284.1[医药卫生—中药学]