血清β-人绒毛膜促性激素与孕酮动态监测对早孕期先兆流产的预测价值  

Forecast value of serum β-HCG and progesterone monitoring on threatened abortio during early pregnancy

作　　者：贾亚楠[1] 白华[1] 李明静[1] 纪蓓蓓[1] 李帆[1] 公小纪 

机构地区：[1]北京军区北戴河疗养院妇产科,河北北戴河066100 [2]北戴河医院妇产科,河北北戴河066100

出　　处：《药物评价研究》2015年第4期402-404,共3页Drug Evaluation Research

摘　　要：目的探讨血清β-人绒毛膜促性激素(β-HCG)与孕酮(P)动态监测对早孕期先兆流产的预测价值,为临床诊断治疗提供参考。方法选取2011年9月—2013年8月收治的早孕期先兆流产孕妇178例作为研究对象,采用im HCG和黄体酮治疗后,根据妊娠结局分为安胎组(n=132)和流产组(n=46),比较两组治疗前血清β-HCG、P水平及动态监测治疗过程中血清β-HCG、P的变化情况。结果安胎组入院时检测β-HCG≥2 000 IU/m L者占比高达95.45%,而流产组仅有17.39%,两组差异有统计学意义(P<0.001),安胎组入院时检测未出现P水平<15 nmol/L者,而流产组出现P水平<15nmol/L者占比高达73.91%,两组差异有统计学意义(P<0.001);动态监测安胎组血清β-HCG、P呈上升趋势,且β-HCG的增幅较大;流产组血清β-HCG、P呈下降或微弱增长的趋势,两组患者血清β-HCG、P变化差异对比有统计学意义(P<0.05)。结论动态监测早孕期先兆流产血清β-HCG与P水平可作为妊娠结局预后的重要指标。Objective To investigate the forecast value of dynamic monitoring of serum beta human chorionic gonadotropin （β-HCG） and progesterone （P） value on early threatened abortion, and to provide reference for clinical diagnosis and treatment. Methods Pregnant women （178 cases） during the first trimester threatened abortion from September, 2011 to August, 2013 were as the research object, and im injected with HCG and progesterone treatment group （n = 132） and abortion group （n = 46）. The changes of According to the outcome of pregnancy, they were divided into test β-HCG and P content between the two groups before treatment were recorded, and the serum β3-HCG, and P content were dynamic monitored in the course of treatment. Results The occupancy rate detecting L3-HCG ≥ 2 000 IU/mL of test group was high as 95.45%, while that of the abortion group accounted for only 17.39%, with significant difference between two groups （P 〈 0.001）. There were no case detecting P 〈 15 nmol/L in test group, while the occupancy rate detecting P 〈 15 nmol/L in abortion group was high as 73.91%, with statistically significant difference between two groups （P 〈 0.001）. The dynamic monitoring of serum β-HCG and P showed the trend of escalation, and β-HCG increased significantly in test group, while in abortion group the trend of serum β-HCG and P was declined or weak increase, with statistical significance （P 〈 0.05）. Conclusion Dynamic monitoring of serum β-HCG and P levels in threatened abortion in early pregnancy can be used as an important index for prognosis of pregnancy.

关 键 词：血清Β-HCG 孕酮 动态监测 早孕期先兆流产 

分 类 号：R984[医药卫生—药品]