右丙亚胺治疗蒽环类药物诱发静脉炎2例  

Clinical research of the treatment of anthracyclines induced phlebitis with dexrazoxane,2 cases

作　　者：刘东芳[1] 张宝琴[2] 冯小军 张成侠[1] 赵晓亮[1] 李素欣 冯志刚[1] 刘艳芬[1] 刘欣[1] 訾建杰[1] 

机构地区：[1]河北省唐山市人民医院血液科,唐山063000 [2]河北省唐山市人民医院检验科,唐山063000 [3]河北省唐山市新丰区城关镇医院防疫科,唐山063000

出　　处：《西北药学杂志》2015年第5期638-640,共3页Northwest Pharmaceutical Journal

摘　　要：目的观察右丙亚胺在治疗蒽环类药物诱发化疗性静脉炎中的安全性及有效性。方法65岁男性急性髓细胞白血病(M2a)患者静滴蒽环类药物后,左手背出现红肿、疼痛,先后给予硫酸镁外敷、芦荟外敷、土豆外敷,无效,后静脉注射右丙亚胺治疗(500mg,连续5d);38岁男性MDS转急性髓细胞白血病患者给予蒽环类药物后左手背出现红肿、疼痛,即静脉注射右丙亚胺治疗(500mg,连续5d)。临床随访(1个月)评定疗效。结果第1例应用右丙亚胺后4d疼痛减轻,7d红肿消退;第2例给予右丙亚胺治疗次日疼痛减轻,3d红肿消退。2例患者除局部留有轻度色素沉着外,手及前臂功能无影响。结论右丙亚胺治疗蒽环类药物诱发静脉炎行之有效,尽早应用,疗效更佳。Objective The purpose of this study was to assess the efficiency and safety of the treatment of anthracyclines induced phlebitis with dexrazoxane .Methods The first case was a 65 year‐old male patient with acute myelogenous leukemia （M2a） .His left back appeared redness swollen ,and pain after giving anthracyclines .The successively external application with magnesium sul‐fate ,aloe ,and potatoes was ineffective ,then dexrazoxane （500 mg ,5 d） was given intravenously ;The second case was a 38 year‐old male patient with acute myelogenous leukemia transferred by MDS .His left back appeared redness ,swollen ,and pain after giv‐ing anthracyclines dexrazoxane （500 mg ,5 d） .The curative effect was evaluated by clinical follow‐up（1 month） .Results After giving dexrazoxane intravenously ,pain was relieved ,and red faded ,no side effects observed .Conclusion Giving dexrazoxane in‐travenously for phlebitis induced by anthracyclines ,is an effective method .

关 键 词：右丙亚胺 蒽环类药物 静脉炎 

分 类 号：R972[医药卫生—药品]