天麻钩藤饮改善高血压患者血管顺应性和血管内皮功能的临床研究  

Clinical Study on Tianma Gouteng Decoction in Treatment of Patients With Hypertension and Improving Vascular Compliance and Endothelial Function

作　　者：翁锦龙[1] 林恩平[1] 

机构地区：[1]福建中医药大学附属人民医院,福州350004

出　　处：《中国卫生标准管理》2015年第24期124-126,共3页China Health Standard Management

摘　　要：目的以天麻钩藤饮对颈-股动脉脉搏波速度(C-FPWV)、血流介导的血管舒张反应(FMD)和症状分级为主要观察指标,探索天麻钩藤饮改善血管顺应性和血管内皮功能的功效。方法按照诊断标准、纳入标准和排除标准选择原发性高血压1级(肝阳上亢型)患者60例,随机分成2组,中药(中西药=氢氯噻嗪+天麻钩藤饮)治疗组(30例),常规(西药=氢氯噻嗪)治疗组(30例),疗程均为12周,并与正常健康人(30例)比较。结果与正常组比较,高血压患者的C-FPWV加快,中药治疗组C-FPWV较治疗前显著下降(P<0.01),常规治疗组C-FPWV较治疗前无差异(P>0.05),两组比较,中药治疗组C-FPWV下降幅度显著优于常规治疗组(P<0.01)。与正常组比较,高血压患者的FDM显著低于血压正常组,中药治疗组FDM较治疗前显著升高(P<0.01),常规治疗组FMD较治疗前升高无差异(P>0.05),两组比较,中药治疗组FDM升高幅度显著优于常规治疗组(P<0.01)。治疗前后血压及症状分级变化,治疗组与对照组治疗前后血压及症状分级较治疗前显著下降(P<0.01),两组比较,治疗组治疗血压及症状分级下降幅度显著优于对照组(P<0.01)。结论天麻钩藤饮与降压药联合,可有效改善血管顺应性及内皮功能,较单用降压药具有疗效,且可以更好地稳定血压与改善症状。Objective To investigate the effect of Tianma Gouteng Decoction of carotid femoral arterial pulse wave velocity（c-fpwv）,and flow mediated vascular as the main outcome measures were used to assess endothelial（FMD）and symptom classification,in order to explore the Tianma Gouteng Decoction to improve vascular compliance and endothelial function effect.Methods According to the diagnostic criteria, inclusion criteria and exclusion of selection criteria for primary hypertension 1 level（liver yang hyperactivity type）of 60 cases of patients were randomly divided into two groups,TCM（traditional Chinese and Western medicine=hydrogen chlorine thiazide＋Tianma Gouteng Decoction）treatment group（30 cases）, conventional（western medicine=hydrochlorothiazide） treatment group （30 cases）,a course of 12 weeks,and compared with normal healthy people （30 cases）.ResultsCompared with the normal group,the C-FPWV of patients with hypertension was accelerated. The C-FPWV of Chinese medicine treatment group was significantly decreased（P〈 0.01）, and the C-FPWV in the conventional treatment group was not significantly different （P〉 0.05）,and the C-FPWV in the Chinese medicine treatment group was significantly better than that in the conventional treatment group（P〈 0.01）. Compared with normal group, FDM was significantly lower in hypertensive patients than that in normal group（P〈 0.01）,and FMD in the conventional treatment group was not significantly different（P〉 0.05）,the two groups were significantly higher than those in the conventional treatment group（P〈 0.01）. Before and after treatment,blood pressure and symptom classification were changed. The blood pressure and symptom classification before and after treatment were significantly decreased（P〈 0.01）,the two groups compared with the control group was significantly different（P〈 0.01）.Conclusion Tianma Gouteng Decoction and antihypertensive drug can be effective in improving vascular adaptation and endothelial

关 键 词：天麻钩藤饮 动脉脉搏波速度 血流介导的血管舒张反应 高血压 肝阳上亢 氢氯噻嗪 

分 类 号：R544.1[医药卫生—心血管疾病]