儿童金黄色葡萄球菌性烫伤样皮肤综合征(SSSS)168例临床及实验室检测分析  

Clinical and Laboratory Analysis of 168 Cases of Children With Staphylococcus Aureus Burn Like Skin Syndrome(SSSS)

作　　者：马晓慧[1] 

机构地区：[1]河南省人民医院检验科,郑州450003

出　　处：《中国继续医学教育》2015年第24期39-41,共3页China Continuing Medical Education

摘　　要：目的：分析儿童金黄色葡萄球菌性烫伤样皮肤综合征的临床表现、实验室检测结果，及时尽早诊断，减少误诊误治，有效地治疗至关重要，最大程度降低死亡率。方法回顾性分析我科168例住院儿童SSSS的临床特点、实验室检测结果包括血常规及细菌学检测、血培养等，治疗应用万古霉素、头孢曲松钠、头孢克洛干混悬剂等抗感染药物并短程联合糖皮质激素，部分较重患儿静脉滴注丙种球蛋白联合运用。结果168例细菌培养阳性率低，72例培养出金黄色葡萄球菌，96例培养为阴性，血培养全部阴性。全部病例均于2～10 d治愈出院，平均住院（5.1±4.8）d。结论SSSS诱发因素包括蚊虫叮咬等诸多方面，发病主要集中于7～8月，好发年龄3～5岁幼儿。细菌培养阳性率低，72例培养出金黄色葡萄球菌，96例培养为阴性，血培养全部阴性。抗菌素并短程联合糖皮质激素及静脉滴注丙种球蛋白支持取得满意疗效。Objective To analysis of children with staphylococcal scalded skin comprehensive syndrome clinical manifestation, laboratory test results, as soon as possible diagnosis, to reduce the misdiagnosis and mistreatment, effective treatment is essential, to the greatest extent reduce mortality. Methods A retrospective analysis of 168 cases of hospitalized children SSSS in clinical characteristics, laboratory examination results including blood routine examination and bacteriological examination, blood culture, therapeutic application of vancomycin, ceftriaxone sodium, cefaclor dry mixed suspensions and other anti infective drugs and short range combined with glucocorticoid and portions of the heavier children with intravenous gammaglobulin combined. Results The positive rate of bacterial culture was low in 168 cases, 72 cases of staphylococcus aureus, 96 cases were negative, blood culture was negative. All patients were treated with 2~10 d, and the average length of stay was （5.1±4.8） days. Conclusion SSSS inducing factors include many aspects, such as mosquito bites, the main focus of the disease is 7-8 months, good hair age 3～5 years old children.The positive rate of bacterial culture was low, 72 cases of Staphylococcus aureus, 96 cases were negative, blood culture was negative. Antibiotics and short-term combined glucocorticoid and intravenous gamma globulin support with satisfactory results.

关 键 词：头孢曲松钠 头孢克洛 万古霉素 糖皮质激素 丙种球蛋白 

分 类 号：R753[医药卫生—皮肤病学与性病学]