氨氯地平贝那普利片合剂减少高血压伴左室肥厚患者新发房颤的研究  

Study on Amlodipine Besylate and Benazepril Hydrochloride Tablets Mixture in Reducing Hypertension Atrial Fibrillation in Patients With Left Ventricular Hypertrophy

作　　者：宋宏雁[1] 景江新[2] 方志敏[1] 钟小兰[1] 刘顺民[1] 陆云[1] 

机构地区：[1]新疆医科大学第二附属医院心内科,乌鲁木齐830000 [2]新疆医科大学第二附属医院B超室,乌鲁木齐830000

出　　处：《中国继续医学教育》2015年第24期137-139,共3页China Continuing Medical Education

摘　　要：目的比较氨氯地平贝那普利片和单剂减少高血压伴左室肥厚患者新发房颤的效果。方法高血压伴左室肥厚患者256例随机分为三组,氨氯地平组(n=85),贝那普利片组(n=87),氨氯地平贝那普利合剂组(n=84),疗程均为18个月。治疗前后进行血压和超声心动图、动态心电图检查和记录新发房颤和不良反应发生情况。结果治疗后,氨氯地平贝那普利合剂组患者舒张压、收缩压、舒张末期左室后壁厚度、左房内径数值较单药组降低明显(P均<0.05);新发房颤率低于单药组,不良反应发生率低于单药组。结论氨氯地平和贝那普利及氨氯地平贝那普利片,可明显控制患者的血压,逆转左室肥厚和左心房扩大,氨氯地平贝那普利片效果更为显著且安全性较高,且新发房颤发生率较低。Objective To compare amlodipine benazepril tablet and single agent to reduce the morbidity of atrial ifbrillation of hypertension patients with left ventricular hypertrophy. Methods 256 patients with hypertension with left ventricular hypertrophy were randomly divided into three groups, amlodipine group （n=85）, the benazepril tablet group （n=87）, amlodipine benazepril mixture group （n=84）, Course of treatment is 18 months. Before and after treatment, blood pressure and echocardiography, dynamic electrocardiogram inspection and new atrial fibrillation and adverse reactions occur were been recorded. Results After treatment, the numerical value of amlodipine benazepril mixture group of patients including diastolic blood pressure, systolic pressure, diastolic left ventricular wall thickness, left atrial diameter value lower than single drug group was obviously, （P〈0.05）. New af rate is lower than single drug group, incidence of adverse reactions obviously lower than single drug group. Conclusion Amlodipine benazepril tablet is an effective drug to treat hypertension with left ventricular hypertrophy, can obviously control the patient＆#39;s blood pressure and reverse left ventricular hypertrophy and left atrial enlargement, more signiifcant effect and higher security, lower incidence of atrial ifbrillation.

关 键 词：氨氯地平贝那普利片 高血压 左室肥厚 新发房颤 

分 类 号：R541.3[医药卫生—心血管疾病]