沙格列汀联合二甲双胍治疗2型糖尿病的临床观察  

Clinical Observation of Saxagliptin Combined with Metformin in the Treatment of Type 2 Diabetes

作　　者：刁幼林[1] 于建华[1] 王娟[1] 

机构地区：[1]娟解放军第148医院,山东淄博255300

出　　处：《中国药房》2015年第27期3761-3763,共3页China Pharmacy

摘　　要：目的:观察沙格列汀联合二甲双胍治疗2型糖尿病的疗效和安全性。方法:95例2型糖尿病患者随机分为观察组(47例)和对照组(48例)。入组前所有患者均给予盐酸二甲双胍缓释片0.5 g,口服,3次/日,连用4周;在此基础上,对照组患者继续给予盐酸二甲双胍缓释片0.5 g,口服,3次/日,连用24周;观察组患者在对照组治疗的基础上给予沙格列汀片5 mg,口服,1次/日,连用24周。两组患者疗程均为28周。观察两组患者的临床疗效,治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、睡前血糖、糖化血红蛋白(Hb A1c)、体质量指数(BMI),低血糖、严重低血糖发生率及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,低血糖发生率显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者血糖指标均显著低于同组治疗前,且观察组FPG、Hb A1c低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗前后BMI、严重低血糖发生率、不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:沙格列汀联合二甲双胍治疗2型糖尿病较单用二甲双胍疗效更显著,安全性较好,可显著降低低血糖发生率。OBJECTIVE： To observe the clinical efficacy and safety of saxagliptin combined with metformin in the treatment of type 2 diabetes. METHODS： A total of 95 patients with type 2 diabetes were randomly divided into observation group（47 cases） and control group（48 cases）. All of the patients received Metformin hydrochloride sustained-release tablets 0.5 g for continuous 4 weeks, orally, 3 times a day; based on the treatment, control group was continuously given Metformin hydrochloride sustained-re- lease tablets 0.5 g for continuous 24 weeks, orally, 3 times a day; observation group was given Saxagliptin tablets 5 mg continu- ous 24 weeks based on the treatment of control group, orally, once a day; the treatment course was 28 weeks. The clinic data was observed, including clinical efficacy, FPG, 2 h PG,bed time glucose, HbAlc, BMI before and after treatment, incidence of hypoglyce- mia, severe hypoglycemia and adverse reactions. RESULTS： The total effective rate in observation group was higher than control group, the incidence of hypoglycemia in observation group was lower than control group（P〈0.05）. After treatment, the glucose in- dexes in 2 groups was significantly lower than before, and FPG and HbA^c in observation group were lower than control group（P〈 0.05）. There were no significant differences in the BMI before and after treatment, incidence of severe hypoglycemia and adverse reactions between 2 groups（P〉0.05）. CONCLUSIONS： Saxagliptin combined with metformin has better efficacy and safety than metformin alone in the treatment of type 2 diabetes, and can significantly reduce the incidence of hypoglycemia.

关 键 词：沙格列汀 二甲双胍 2型糖尿病 疗效 安全性 

分 类 号：R587.1[医药卫生—内分泌]