中国人群CYP4F2基因多态性对华法林维持剂量影响的系统评价  

Effect of CYP4F2 Gene Polymorphism on Warfarin Maintenance Dose in Chinese Population:a Systematic Review

作　　者：史长城[1] 田港[2] 楼江[1] 严伟[1] 

机构地区：[1]杭州市第一人民医院药学部,杭州310006 [2]浙江中医药大学人事处,杭州310053

出　　处：《中国药房》2015年第27期3803-3805,共3页China Pharmacy

基　　金：浙江省药学会医院药学专项科研资助项目(No.2014ZYY18)

摘　　要：目的:系统评价中国人群CYP4F2基因多态性与华法林维持剂量的关系,以为临床治疗提供循证参考。方法:计算机检索Cochrane图书馆、Pub Med、EMBase、中国期刊全文数据库、中文科技期刊数据库和万方数据库,收集中国人群CYP4F2基因多态性与华法林维持剂量关系的研究,提取资料并进行质量评价后,采用Rev Man 5.0统计软件进行Meta分析。结果:共纳入13项研究,合计2 958例患者,基因检测结果分为TT、CT和CC型。Meta分析结果显示,CYP4F2的3种基因型华法林稳定剂量的关系为:TT型>CT型>CC型,各组间比较差异均有统计学意义。结论:中国人群CYP4F2基因多态性与华法林维持剂量有显著相关性。受纳入研究方法学质量的限制,该结论有待大样本、高质量的研究进一步验证。OBJECTIVE：To systematic review the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population, and to provide evidence-based reference for clinical treatment. METHODS： Retrieved from Cochrane library, PubMed, EMBase, CJFD, VIP and Wanfang database, studies about the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population were collected, and Meta-analysis was performed by using Rev Man 5.0 statis- tics software. RESULTS： A total of 13 studies were included, involving 2 958 patients. The type of gene was type TT,type CT and type CC. Results of Meta-analysis showed the relationship between 3 gene polymorphism and warfarin maintenance dose was type TT〉type CT〉type CC, and there were significant differences among groups. CONCLUSIONS： CYP4F2 gene polymorphism in Chinese population has significant correlation with warfarin maintenance dose. However, due to the limit of methodological quali- ty, large-scale and high quality studies are required for further validation of the conclusions.

关 键 词：华法林 CYP4F2 基因多态性 系统评价 维持剂量 

分 类 号：R971[医药卫生—药品]