胡椒提取物缓释滴丸的制备工艺研究  

Study on Preparation Technology of Sustained-Release Dropping Pills of Fructus Piperis Extract

作　　者：赵红艳[1] 涂婷[2] 罗海燕[1] 

机构地区：[1]海南医学院,海南海口571101 [2]成都中医药大学,四川成都611137

出　　处：《成都中医药大学学报》2015年第3期38-42,共5页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：成都中医药大学中药学国家级重点学科;中药资源系统研究与开发利用省部共建国家重点实验室培育基地开放研究基金资助项目

摘　　要：目的:研究胡椒提取物缓释滴丸的制备方法及其体外释放特征。方法:通过固体分散技术,以硬脂酸为骨架材料,以聚乙二醇—6000为致孔剂,通过选择适当的药物与辅料比,制得具有良好缓释效果的胡椒提取物缓释滴丸。采用转篮法,选择合适的溶出介质,研究其体外释放特征。结果:聚乙二醇—6000与硬脂酸的联合应用可制得外观圆整,质地均匀的胡椒提取物缓释滴丸,胡椒提取物:基质(硬脂酸与PEG6000的比例为1:5)=1:4具有较好的缓释效果,溶出介质为加SDS的磷酸缓冲液其体外释药行为可由Higuchi方程拟合方程为Q=0.3297 t1/2-0.2095。结论:所制得的胡椒缓释滴丸具有良好的缓释效果,且制备工艺简单。Objective： To study the preparation methods and the in vitro release characteristics of the sustained-release dropping pills of Piperis Fructus extract （Fru SDP） . Methods： Fru SDP were prepared by solid dispersion method with stearic acid as an eroding matrix and PEG-6000 as a pore-forming agent. Its release characteristics were studied by the rotating basket method. Results： Round and homogeneous Fru SDP were prepared by the combination of stearic acid and PEG-6000. The optimized formula was as follows ： Piperis Fructus extract accounted for 20%, the ratio of stearic acid and PEG 6000 was 1 ： 4 ; the drug release in vitro followed the Higuchi equation of Q = 0. 3297tl/2-0. 2095. Conclusion： Fru SDP is an ideal sustained-release agent and the preparation process is simple.

关 键 词：胡椒碱 缓释制剂 滴丸 释放度 

分 类 号：R284.2[医药卫生—中药学] R285[医药卫生—中医学]