参苓白术颗粒预防老年抗生素相关性肠道菌群失调的RCT研究  

RCT Study On Antibiotic Associated Intestinal Dysbacteriosis In Senile Patients' Prevention of Shen-Ling-Bai-Zhu Granule

作　　者：滕晋[1] 王丹[1] 向露[1] 徐熙[1] 张维[1] 许晋[1] 

机构地区：[1]四川省医学科学院.四川省人民医院干部医疗科,四川成都610072

出　　处：《成都中医药大学学报》2015年第3期52-54,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：四川省科技厅科技支撑项目(编号:2015SZ0164);四川省卫生厅项目(编号:30305020840)

摘　　要：目的：观察参苓白术颗粒对住院老年人抗生素相关性肠道菌群失调的防治作用。方法：选择2012年5月~2014年5月住院老年重症肺炎患者100例,随机分配至对照组（单用美罗培南）和研究组（美罗培南＋参苓白术颗粒）,疗程14 d,治疗结束后判定疗效和菌群失调发生的情况。结果：美罗培南对老年重症肺炎患者有效果良好,对照组与研究组的有效率分别为68%和74%（P〉0.05）;研究组患者肠道菌群失调的发生率、肠道二重感染的发生率显著低于对照组（P〈0.05）。结论：参苓白术颗粒用于预防住院老年患者抗生素相关性肠道菌群失调的发生疗效显著,可用于临床推广。Objective： Observation of Shen-ling-bai-zhu granule in hospitalized elderly patients with antibiotic associated intes- tinal dysbacteriosis in prevention and treatment. Methods： From May 2012 to May 2014, 100 cases of hospitalized elderly patients with severe pneumonia were randomly assigned to control group （ meropenem monotherapy） and study group （ meropenem ＋ Shenling Baizhu particles） and treatment for 14 days, after the end of treatment determination curative effect and bacteria group happen disorder. Results： Meropenem for elderly patients with severe pneumonia has good effect, the control group and study group efficiency were 68% and 74% （P 〉 0. 05） ; the study group patients with intestinal microflora disorders occur rate and intestinal double infection incidence was significantly lower than that of the control group （P 〈 0. 05 ）. Conclusion： Shen-ling-bai-zhu granule for the prevention of elderly hospitalized patients with antibiotic associated intestinal dysbacteriosis occurred significant effect, and it can be used for clinical promotion.

关 键 词：参苓白术颗粒 老年 重症肺炎 抗生素相关性肠道菌群失调 

分 类 号：R285[医药卫生—中药学] R285.6[医药卫生—中医学]