羟考酮及氨酚羟考酮在癌痛治疗中的应用  

Application of oxycodone and oxycodone-acetaminophen in the treatment of cancer pain

作　　者：张帆[1] 李虹义[2] 刘端祺[2] 

机构地区：[1]广州军区武汉总医院肿瘤中心,武汉430070 [2]北京军区总医院,北京100700

出　　处：《中国新药杂志》2015年第18期2077-2080,2084,共5页Chinese Journal of New Drugs

摘　　要：WHO三阶梯止痛原则发布迄今已近30年,各国指南也根据临床中的实际情况,对其进行了进一步改良和发展。由过去"主流"的即释吗啡滴定换算,发展到羟考酮直接滴定法共存,由过去的三阶梯逐步用药,发展到尝试淡化二阶梯、同时一阶梯和三阶梯联合用药。治疗方案虽然在不断的演变,但其核心指导原则并没有变化,即镇痛效果好、用药简单、毒副作用小。由于使用的便利性、镇痛效果相当、毒副作用轻,在可预期的未来,羟考酮和氨酚羟考酮还将在癌痛治疗中扮演重要的角色。It has been almost 30 years since WHO published the three-ladder guidelines for the manage- ment of cancer-related pain. Based on WHO＇s principles, many countries developed or improved their own guide- lines according to clinic advances, respectively. The newly developed oxycodone titration is coexisting with the ＂main-stream＂ morphine titration; the traditional three-ladder treatment process is evolving into a combined-process for ladder I and III, while ladder II is phasing out. Although the therapeutic regimen has been changing, the core principles remain the same： effectiveness, convenience to use, and few side effects. Because oxycodone and oxyc- odone-acetaminophen are easy to use, good at pain control and having less side effects, in foreseeable future, they will play a more important role in the management of cancer-related pain.

关 键 词：羟考酮 氨酚羟考酮 癌痛治疗 

分 类 号：R971[医药卫生—药品] R969.4[医药卫生—药学]