带状疱疹后神经痛的药物治疗  

Pharmacological treatment of postherpetic neuralgia

作　　者：马冰洁[1] 马柯[1] 

机构地区：[1]上海交通大学医学院附属新华医院疼痛科,上海200092

出　　处：《中国新药杂志》2015年第18期2091-2095,共5页Chinese Journal of New Drugs

摘　　要：带状疱疹后神经痛是一种常见的神经病理性疼痛,它严重影响患者的生理和心理。目前公认的一线药物有三环类抗抑郁药或加巴喷丁/普瑞巴林;二线药物包括强阿片类药物和辣椒素乳膏。局部用利多卡因是否作为一线药物尚存在争议。带状疱疹后神经痛建议联合用药,尤其是联用局部5%利多卡因贴片和口服药物。新的治疗药物A型肉毒素(BTX-A)和KAI-1678还需进一步研究。Postherpetic neuralgia （PHN） is a common type of neuropathic pain, which has a serious effect on patients＇ physical and social functions. Nowadays, tricyclic antidepressants, gabapentin or pregabalin are gener- ally recognized as the first-line medicine for treating PHN. The second-line treatment drugs contain strong opioid drugs and capsaicin cream. Whether topical lidocaine is used as the first-line drug is still controversial. Combina- tion of drugs is recommended, especially topical 5% lidocaine patch combined with an oral agent. As new drugs, BTX-A and KAI-1678 still need further study.

关 键 词：带状疱疹后遗神经痛 药物治疗 神经病理性疼痛 

分 类 号：R971[医药卫生—药品]