氨酚羟考酮联合卡马西平治疗带状疱疹后遗神经痛的临床观察  

Safety and efficacy of oxycodone/acetaminophen combined with carbamazepine in the treatment of postherpetic neuralgia

作　　者：张然[1] 沈爱蓉[1] 李兆生[1] 

机构地区：[1]北京市顺义区空港医院疼痛科,北京101318

出　　处：《中国新药杂志》2015年第18期2139-2141,共3页Chinese Journal of New Drugs

摘　　要：目的:观察氨酚羟考酮联合卡马西平治疗带状疱疹后遗神经痛(postherpetic neuralgia,PNH)的疗效和安全性。方法:90名PHN患者随机分为氨酚羟考酮组(A组,n=45)和氨酚羟考酮片联合卡马西平联合治疗组(B组,n=45),治疗4周。观察各治疗组治疗前后疼痛缓解强度(VAS评分)变化、镇痛有效率及不良反应。结果:联合治疗组的镇痛显效率高于氨酚羟考酮组(P<0.05);两组的药物不良反应主要表现为头晕、嗜睡、恶心、呕吐,不良反应的总发生率无显著差异。结论:氨酚羟考酮联合卡马西平治疗PHN,镇痛效果良好,安全可靠,是PHN止痛可供选择的措施之一。Objective： To evaluate the safety and efficacy of oxycodone/acetaminophen （tylox） combined with carbamazepine in the treatment of postherpetic neuralgia （PHN）. Methods： Ninety adult patients with PHN were randomly divided into two groups, and treated with tylox alone （n = 45） and tylox combined with carbamaz- epine （n = 45） for 28 days. Visual Analogue Scale （VAS） pain score changes, efficacy rate of relieving pain and the side effects were observed before and after treatment. Results： The VAS value was significantly lower in combi- nation group than in tylox alone group （P 〈 0.05）. The common adverse events were dizziness, somnolence and vomiting. The overall incidence of side effects was not significant different in two groups. Conclusion： Tylox com- bined with carbamazepine is an effective and safe way in the treatment of postherpetic neuralgia.

关 键 词：带状疱疹后遗神经痛 氨酚羟考酮 卡马西平 

分 类 号：R971[医药卫生—药品]