不同病理分期老年肝纤维化患者多层CT灌注成像参数变化研究  

A Study on the Changes of Multi-slice CT Perfusion Imaging Parameters in Elderly Patients with Hepatic Fibrosis at Different Pathological Stages

作　　者：王婷[1] 

机构地区：[1]陕西省安康市中心医院影像中心,陕西安康725000

出　　处：《中国CT和MRI杂志》2015年第10期66-69,共4页Chinese Journal of CT and MRI

摘　　要：目的探讨不同病理分期老年肝纤维化患者多层CT灌注成像参数变化情况。方法选取医院收治肝纤维化患者65例作为肝纤维化组,选取25例健康志愿者作为对照组,均行64层螺旋CT肝脏灌注扫描,记录门静脉灌注量(PVP)、肝动脉灌注量(ALP)、肝脏灌注指数(HPI)、血容量(BV)、血流量(BF),并与临床病理分期行对照研究。结果肝纤维化组PVP、BF、BV均分别为(92.26±6.25)ml·100ml-1·min-1、(41.09±3.55)ml·100ml-1·min-1、(126.64±8.52)ml/L均显著低于对照组,HPI为(23.18±2.85)%高于对照组,具有统计学意义(P<0.05);S1期PVP、BF、BV分别为(102.24±3.28)ml·100ml-1·min-1、(45.64±1.36)ml·100ml-1·min-1、(133.75±5.59)m l/L显著高于S 3期、S 4期,H P I为(20.06±2.16)%显著低于S3期、S4期,差异显著(P<0.05);S1期、S2期组间无显著差异,不具统计学意义(P>0.05)。结论64层CT灌注成像参数与老年肝纤维化病理分期存在显著相关性。Objective To investigate the changes of CT perfusion imaging parameters in elderly patients with hepatic fibrosis at different pathological stages.Methods 65 patients with hepatic fibrosis in the hospital were selected as the hepatic fibrosis group and 25 cases of healthy volunteers were selected as the control group. All of them received 64-slice spiral CT hepatic perfusion scanning. The amount of portal vein perfusion （PVP）, hepatic arterial perfusion （ALP）, liver perfusion index （HPI）, blood volume （BV） and blood flow （BF） was recorded and was compared with clinical pathological stage.Results PVP, BF and BV of the hepatic fibrosis group were （92.26±6.25）ml·100ml-1·min-1,（41.09±3.55） ml·100ml-1·min-1 and （126.64±8.52）ml/L, respectively which were significantly lower than those of the control group while HPI （23.18±2.85）% was higher than that of the control group and the differences were statistically significant （P〈0.05）. At S1 stage, PVP, BF and BV were （102.24±3.28）ml·100ml-1·min-1, （45.64±1.36）ml·100ml-1·min-1 and （133.75±5.59）ml/L, respectively which were significantly higher than those at S3 and S4 stage while HPI （20.06±2.16）% was significantly lower than thatat S3 and S4 stage. The differences were significant （P〈0.05）. There was no significant difference between S1 and S2 stage, without statistical significance （P〉0.05）.Conclusion There is a significant correlation between 64-slice CT perfusion imaging parameters and the pathological stages of hepatic fibrosis in elderly patients.

关 键 词：肝纤维化 病理分期 64层 CT灌注成像 

分 类 号：R322.47[医药卫生—人体解剖和组织胚胎学]