慢性心力衰竭患者体内Irisin水平的变化及临床价值的研究  

Change and clinical value of research on Irisin level in patients with chronic heart failure

作　　者：王小龙[1] 刘同祥[1] 赵新祥[1] 徐伟华[1] 李维正[2] 

机构地区：[1]潍坊市人民医院急诊心血管内科,山东省261041 [2]潍坊医学院,山东省261041

出　　处：《中华临床医师杂志（电子版）》2015年第16期18-21,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的检测不同心功能分级的慢性心力衰竭（CHF）患者和正常对照组外周血清Irisin（鸢尾素）的水平，研究Irisin在CI-IF中的临床价值。方法选自2013年l～7月在潍坊市人民医院心内科住院的CHF患者45例，并根据NYHA分级将患者分为三组，其中心功能II级患者12例，心功能Ⅲ级患者15例，心功能Ⅳ级患者18例，另选年龄、性别、体质量指数（bodymassindex，BMI）相匹配的，且左心室射血分数（LVEF）〉50％的健康对照组20例。采用生物素双抗体夹心酶联免疫吸附（ELISA）测定血清Irisin水平，并完成心电图（ECG）、LVEF、空腹血糖、心功能等常规检查项目。比较健康对照组与心力衰竭组不同心功能分级及不同亚组间的Irisin差异，并对Irisin与相关因素进行相关性分析。结果（1）4组受试者年龄、性别、BMI比较，差异无统计学意义（P〉0．05），资料具有可比性。（2）心力衰竭组Irisin浓度显著低于健康对照组（P〈O．05），且在NYHA分级Ⅱ、Ⅲ和Ⅳ级患者中逐渐降低。（3）心力衰竭组的LVEF较健康对照组显著降低（P〈0．05），在NYttA心功能Ⅱ、Ⅲ、Ⅳ级间逐渐下降。（4）单因素相关分析显示：Irisin与LVEF呈正相关（r=0．694，P〈0．05）。结论（1）在CHF患者中血清Irisin浓度较健康对照组显著降低，且随着心功能NYHA分级严重程度的加重而逐渐降低，故可以作为CHF的血清生物标记物用于CHF的诊断及鉴别诊断，并为CI-IF的治疗提供了新的思路。（2）Irisin与LVEF呈正相关，可以反映心功能的情况。Objective To test the levels of peripheral blood Irisin in different heart function classification of patients with chronic heart failure （CHF） and normal control group, and evaluate Irisin diagnostic value in CHF. Methods From January 2013 to July 2013 collected 45 patients of chronic heart failure in my Department of Cardiology Weifang People＇s Hospital, and according to NYHA classification heart failure group were divided into 3 groups, 12 cases were cardiac function class Ⅱ, 15 patients cardiac function grade HI, 18 patients cardiac function level IV, another age, gender, body mass index （BMI） phase matching, and left ventficular ejection fraction （LVEF）〉50% healthy control group of 20 cases were selected. Using biotinylated double antibody sandwich enzyme linked immunosorbent assay （ELISA） to determinate the serum Irisin level, and completed the electrocardiogram （ECG）, LVEF, fasting blood glucose, heart function routine inspection project. Compared the difference of Irisin in healthy control group and heart failure group without classification of cardiac function and different sub groups, Irisin and related factors were analyzed. Results （1）Comparison of age, gender, BMI in 4 groups was no significant difference （P〉0.05）. （2）Irisin in heart failure group was significantly lower than that in healthy control group （P〈0.05）, and decreased gradually in NYHA grade Ⅱ, HI, IV level in patients. （3）LVEF in heart failure group than the healthy control group decreased significantly （P〈0.05）, decreased in cardiac function

关 键 词：心力衰竭 脂肪组织 棕色 运动 鸢尾素 

分 类 号：R541.6[医药卫生—心血管疾病]