Th细胞相关因子与系统性红斑狼疮  

T-helper cell associated cytokines in systemic lupus erythematosus

作　　者：吴萌[1] 杨金华[1] 介绍亮[2] 闫成兰[1] 陈俊伟[1] 

机构地区：[1]山西医科大学第二医院风湿免疫科,太原030001 [2]临汾市人民医院风湿科,山西省041000

出　　处：《中华临床医师杂志（电子版）》2015年第16期75-79,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省科技攻关项目(20150313008-2)

摘　　要：系统性红斑狼疮是一种异质性自身免疫性疾病,其发病机制尚未明确,但常涉及免疫系统的紊乱。正常免疫应答的发生、调节和保持,需要所有T细胞亚群的功能处于一种平衡状态。因此,T细胞亚群分布紊乱及其不同亚群的活化和功能异常在SLE发生发展中有重要作用。而其中,其分泌的细胞因子网络的紊乱处于中心位置。本文就Th细胞相关因子在SLE中的产生及功能异常,分析它们可能的致病机制以及作为治疗靶点的可能性。Systemic lupus erythematosus （SLE） is a heterogenic autoimmune inflammatory disease. Though the pathogenesis of SLE is still incompletely deciphered, the disorder of immune is involved. The functional homeostasis of T ceil subsets is required for the occurrence, regulation and maintenance of normal immune response. Thus, the abnormal distribution, activation or function of T cell subsets play a crucial role in the development of SLE. Among them, the dysregulation of cytokines networks in the center position. In this paper, we elaborated on the abnormal secretion and functions of T helper （Th） cell associated cytokines in SLE, analyzed their potential pathogenic roles, and probed into the possibility of them being utilized as targets for therapy.

关 键 词：红斑狼疮 系统性 T淋巴细胞 辅助诱导 细胞因子类 

分 类 号：R593.241[医药卫生—内科学]