奥美沙坦对糖尿病大鼠腹主动脉球囊损伤后内膜增生的影响  

Effects of Olmesartan on neointima hyperplasia after balloon injury of abdominal aorta in diabetic rats

作　　者：张永红[1] 董颀[2] 熊龙根[1] 

机构地区：[1]广州医科大学附属第二医院心血管内科,广州心血管疾病研究所 [2]广州医科大学生理教研室,广州510182

出　　处：《广东医学》2015年第15期2319-2322,共4页Guangdong Medical Journal

基　　金：广东省自筹经费类科技计划项目(编号:粤科函规财字[2014]807号-4)

摘　　要：目的探讨链脲佐菌素(Streptozocin,STZ)诱导的糖尿病(DM)大鼠腹主动脉在球囊损伤术后血管内膜、C反应蛋白(CRP)及白细胞介素-6(IL-6)的变化及奥美沙坦对其的影响。方法以STZ诱导DM大鼠模型,将DM大鼠随机分为假手术组(C组)、奥美沙坦治疗组(OM组)和球囊损伤组(BI组)。3组均于术后第1天至术后28 d开始灌胃,术后28 d取材,检测腹主动脉内膜面积(I)、中膜面积(M)及内膜与中膜的面积比(I/M)。ELISA法检测血浆中CRP及IL-6含量。结果与C组比较,BI组及OM组内膜明显增厚(P<0.05),血浆中CRP、IL-6水平明显升高(P<0.05);与BI组比较,OM组血管内膜增厚减轻(P<0.05),CRP、IL-6的水平升高减低(P<0.05)。结论奥美沙坦能部分减轻糖尿病大鼠腹主动脉球囊损伤后血管再狭窄的发生,其防治再狭窄的机制可能与降低血浆中CRP、IL-6的水平有关。Objective To investigate the alterations of C - reactive protein （CRP） and IL - 6 after balloon injury of abdominal aorta in Streptozocin（STZ） induced diabetic rats and the effects of olmesartan on the alterations. Methods STZ induced diabetic rats were randomly divided into three groups： sham surgery group（ Group C）, balloon injury plus olmesartan group（ Group OM） , and balloon injury group （Group BI）. Since the first day after balloon injury, the three groups had been garaged until 28 days after surgery. Specimens of abdominal aortas were obtained for the following evalua- tion： intimal area（I）, medial area（M）, the intimal/medial area ratio, all with HE staining. Plasma CRP and IL-6 in each group were measured with ELISA. Results Significant hyperplasia of neointima, elevated plasma C RP and IL -6 concentration were revealed in Group BI and Group OM compared with Group C （P 〈 0. 05）. Less neointima hyperplasia, lower CRP and IL -6 concentrations were detected in Group OM vs. Group BI（P 〈 0. 05）. Conclusion Olmesartan par- tially alleviates restenosis after abdominal aorta balloon injury in STZ induced diabetic rats, perhaps via depression of plas- ma CRP and IL- 6.

关 键 词：奥美沙坦 再狭窄 C反应蛋白 白细胞介素-6 

分 类 号：R977.21[医药卫生—药品]