风湿性疾病患者25-羟-维生素D水平及其与心血管疾病关系的研究  

Expression and significance of 25-hydroxy vitamin D in rheumatic disease patients and the risk between it and cardiovascular disease

作　　者：李金潺 温鸿雁[1] 李小峰[1] 卫丹丹[1] 

机构地区：[1]山西医科大学第二医院风湿免疫科,太原030001

出　　处：《中华风湿病学杂志》2015年第9期611-613,共3页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（81301532）;山西省回国留学人员科研资助项目（2013-118）

摘　　要：目的 研究风湿性疾病患者血清25-羟-维生素D[25（OH）D]水平及与心血管疾病发生风险的关系,并探讨其临床意义.方法 收集资料完整的134例风湿性疾病患者,回顾性分析血清25（OH）D水平、骨密度及相关临床资料.计量资料比较采用独立样本t检验.结果 合并心血管疾病组D25（OH）D水平为（13±8） ng/ml,尚无心血管疾病组为（14±8） ng/ml,2组差异无统计学意义（t=0.638,P＞0.05）.但2组TC、TG、HDL-C、LDL-C、载脂蛋白A、载脂蛋白B、脂蛋白-α水平差异有统计学意义（t=3.314、3.397、3.092、2.159、3.621、2.011、2.066,P均＜0.05）,骨密度水平低于尚无心血管疾病组（t=-16A31,P＜0.05）.结论 风湿性疾病患者血清25（OH）D水平与心血管疾病的伴发可能有一定的关系.Objective To explore the expression and significance of 25-hydroxy vitamin D [25（OH）D] in rheumatic disease patients,and its association with the risk of cardiovascular disease （CVD）.Methods The level of 25（OH）D,bone mineral density （BMD） test and clinical indicators of 134 rheumatic disease cases were analyzed retrospectively.T test was used for statistical analysis.Results Patients who were combined with CVD and rheumatic disease,the level of 25-hydroxy vitamin D was （13±8） ng/ml,who were without CVD the level was （14±8） ng/ml.There was no significant difference between two groups（t=0.638,P〉0.05）.But patients who were complicated with CVD and rheumatic diseases,their TC,TG,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol （LDL-C）,apolipoprotein （Apo） A,ApoB and lipoprotein levels were higher than patients who were without CVDs （t=3.314,3.397,3.092,2.159,3.621,2.011,2.066,both P〈0.05）,and their BMD was lower than patients who were without CVDs （t=-16.131,P〈0.05）.Conclusion To a certain extent,serum 25（OH）D levels of patients with rheumatic diseases is associated with CVD.

关 键 词：风湿性疾病 心血管疾病 维生素D 骨密度 25-羟-维生素D 

分 类 号：R593.2[医药卫生—内科学] R54[医药卫生—临床医学]