脑功肽口服液抗焦虑作用实验研究  

Experimental Study of Anxiolytic Effects of Naogongtai Oral Liquid

作　　者：雷健[1] 胡长鹏[1] 邢茂[1] 向俊马 张蓉[1] 

机构地区：[1]中国人民解放军第三军医大学新桥医院药学部,重庆400037

出　　处：《中国药业》2015年第18期19-20,共2页China Pharmaceuticals

基　　金：重庆市卫生局中医药科技项目;项目编号:ZY20132151

摘　　要：目的通过动物行为学试验模型研究脑功肽口服液的抗焦虑作用。方法采用小鼠高架十字迷宫试验(EPM)和大鼠敞箱试验(OFT),EPM试验选取开臂时间百分比(OT%)、开臂次数百分比(OE%)、总入臂次数、总入臂时间为观察指标;OFT试验选取总路程、中央区域路程、中央区域时间为观察指标。分别设空白对照组、地西泮组、脑功肽高剂量组与脑功肽中剂量组进行观察。结果在EPM试验中,OT%与OE%地西泮组分别为(51.23±17.47)%和(53.28±14.96)%,脑功肽高剂量组分别为(38.67±15.23)%和(57.43±8.16)%,均与空白对照组有显著性差异(P<0.05);OFT试验中,地西泮能显著增加中央区域时间(P<0.05)。结论 EPM试验显示,脑功肽口服液具有抗焦虑作用。Objective To assess the anxiolytic effects of Naogongtai Oral Liquid through animal behavior experimental model. Methods The elevated plus maze（EPM） test and open field test（OFT） were adopted;in EPM test the observation indicators were open arm entry%（OT%）,open arm time%（OE%）,total entry and total entry time,in OFT the observation indicators were total path,central area time,central area path. These indicators were observed in blank control group,diazepam group,Naogongtai high dose group and Naogongtai medium dose group. Results In EPM test,OT% and OE% were （51. 23 ± 17. 47）% and （53. 28 ± 14. 96）% respectively in diazepam group,and （38. 67 ± 15. 23）% and （57. 43 ± 8. 16）% respectively in Naogongtai high dose group,both of them were significantly higher than the blank control group（ P ﹤ 0. 05）. In OFT,the central area time was significantly increased in diazepam group（ P ﹤ 0. 05）. Conclusion The EPM test shows that Naogongtai Oral Liquid has anti-anxiety effect.

关 键 词：脑功肽口服液 焦虑 高架十字迷宫试验 大鼠敞箱试验 

分 类 号：R285.5[医药卫生—中药学] R286[医药卫生—中医学]