二乙酰氨乙酸乙二胺治疗肝硬化消化道出血52例疗效评价  

Clinical Efficacy of Ethylenediamine Diaceturate for Treating Liver Cirrhosis with Gastrointestinal Hemorrhage in 52 Cases

作　　者：徐凤华[1] 董月华[1] 薛净[1] 李明[1] 

机构地区：[1]武警北京总队医院,北京100027

出　　处：《中国药业》2015年第18期49-50,共2页China Pharmaceuticals

摘　　要：目的探讨二乙酰氨乙酸乙二胺治疗肝硬化消化道出血的临床疗效。方法将104例患者随机分为对照组和观察组,各52例。对照组患者在卧床休息、禁食、静脉补充电解质和水、抗感染等内科常规治疗基础上使用奥曲肽止血,观察组患者则将止血药物换为二乙酰氨乙酸乙二胺,其余治疗方案相同。结果治疗后,观察组总有效率为73.08%,明显高于对照组的59.61%(P<0.05);两组患者治疗后的血红蛋白及脉率较治疗前显著降低(P<0.05),但组间比较无明显差异(P>0.05);两组已止血患者1周后复发率,观察组为5.26%,显著低于对照组的12.90%(P<0.05);治疗前后凝血功能及血小板功能变化情况,观察组有显著好转(P<0.05),对照组未见明显变化(P>0.05);两组患者药品不良反应发生率间未见显著性差异。结论二乙酰氨乙酸乙二胺治疗肝硬化合并消化道出血疗效确切,安全性高,能显著降低患者已止血后的复发率。Objective To investigate the efficacy of ethylenediamine diaceturate in treating liver cirrhosis with gastrointestinal hemorrhage. Methods Totally 104 patients were randomly divided into the control group and the observation group,52 cases in each group. The control groups used octreotide hemostasis treatment on the basis of routine internal medicine treatment,the observation group were given ethylenediamine diaceturate to replace the hemostatic drug,and the other treatment remained unchanged. Results After treatment,the total effective rate of the observation group was 73. 08%,which was obviously higher than 59. 61% of the control group （ P ﹤ 0. 05 ）;the hemoglobin and pulse rate of the two groups were significantly decreased（ P ﹤ 0. 05）,but there was no significant difference between the two（ P ﹥ 0. 05）;the recurrence bleeding rate of the observation group was 5. 26%,which was significantly lower than 12. 90% of the control group（ P ﹤ 0. 05）;the coagulation function and platelet function in the observation group improved significantly（ P ﹤ 0. 05）,and the control group showed no significant change（ P ﹥ 0. 05）. The adverse reactions of the two groups had no significant difference. Conclusion Ethylenediamine diaceturate in treating liver cirrhosis with upper gastrointestinal hemorrhage has exact effect,and good safety and can significantly reduce the recurrence rate after patients stopped bleeding.

关 键 词：二乙酰氨乙酸乙二胺 肝硬化 消化道出血 复发 

分 类 号：R969.4[医药卫生—药理学] R973.1[医药卫生—药学]