中山市213例HIV/AIDS病人配偶HIV抗体检测及随访情况分析  

Analysis of the HIV antibody test and the follow up of the spouse of 213 HIV/AIDS in Zhongshan city

作　　者：王曼[1] 孙映梅[1] 李雷[1] 陈楚莹[1] 来学惠[1] 陈建海[1] 汪涛[1] 

机构地区：[1]中山市疾病预防控制中心,广东中山528403

出　　处：《中国艾滋病性病》2015年第9期766-769,共4页Chinese Journal of Aids & STD

基　　金：国家"十二五"重大专项(2012ZX10004-902)~~

摘　　要：目的 了解广东省中山市艾滋病病毒（HIV）感染者和艾滋病（AIDS）病人（简称HIV/AIDS病人）的配偶HIV抗体检测及随访HIV抗体阳转情况。方法 从国家艾滋病综合防治信息系统中下载病例报告信息和随访信息,采用SPSS分析2010-2012年中山市新发现的已婚HIV/AIDS病人的配偶检测及随访情况,随访信息截止时间为2013年12月31日。结果 213例已婚HIV/AIDS病人被纳入分析,175例（82.2%）的配偶接受过HIV检测,其中41.1%（72/175）的配偶首次检出HIV抗体阳性。女性病例配偶的HIV抗体阳性率是男性病例配偶抗体阳性率的2.31倍[相对危险度（RR）=2.31,95%可信区间（CI）：1.62~3.3]。文化程度越高,配偶HIV抗体阳性率越低（趋势χ2=5.73,P=0.02）。配偶接受HIV抗体检测的HIV/AIDS病人中,100例在确诊后2个月内进行了CD＋4T淋巴细胞（简称CD4细胞）计数检测,其中47例〈200个/μL,26例200~349个/μL;CD4细胞〈350个/μL的配偶HIV抗体检测阳性率是CD4细胞≥350个/μL病例配偶的2.28倍（RR=2.28,95%CI：1.09~4.79）。配偶首次检测HIV抗体阴性的103例HIV/AIDS病人中,68例（66.0%）的配偶完成随访≥1次,合计随访81.8人年,其中1例出现阳转,阳转率为1.22/100人年（95%CI：0~3.6/100人年）。结论中山市发现已婚HIV/AIDS病人,配偶首次检测HIV阳性率高。今后工作应促进病例早发现,提高配偶HIV检测率和随访率。Objective To understand the Human immunodeficiency virus （HIV） antibody test and HIV seroconvertion during follow-up of the spouse of the reported HIV/AIDS. Methods The case report basic data and follow-up data of Zhong- shan city were downloaded from the national AIDS comprehensive manage system. SPSS was used to analyze the HIV antibody test and follow-up data of the spouse of the new reported HIV/AIDS who were married during 2010 to 2012 in Zhongshan cit- y, and the expiration date of follow-up data was 31st December, 2013. Results A total of 213 married HIV/AIDS cases were included for data analysis, and the spouses of 175 married HIV/AIDS cases had HIV test, which accounted for 82. 2%, 41.1% （72/175） of the spouses were HIV positive for the first HIV test. The HIV positive rate of the spouses of the female cases was 2. 31 times （RR=2. 31, 95%CI： 1.62-3. 30） as high as that of the spouses of the male cases. The higher the educa- tion level of the cases, the lower the HIV positive rate of the spouses （χ2 =5. 73, P=0. 02）. Among the 100 cases whose spouses had HIV antibody test and also had CD4＋ T-cell counts within 2 months of the HIV confirmation, the CD4＋ T-cell counts were less than 200 cells per cubic millimeter for 47 cases, and 200 - 349 cells per cubic millimeter for 26 cases. The HIV positive rate among those whose spouse with CD4＋ T-cell counts less than 350 cells per cubic millimeter was 2. 28 times （RR= 2. 28, 95%CI： 1.09 -4. 49） as high as that of those whose spouse with CD＋ T-cell counts 350 or more cells per cubic millime ter. Among the 103 cases whose spouse had HIV negative test during the first time, 68 （66.0%） cases＇ spouses had follow-up HIV test. A total of 81.8 person years were followed with only one HIV seroconvertion, and the HIV seroconvertion rate was1.22 per 100 person-years （95% CI： 0-3. 6/100 person-years）. Conclusion Among the reported married HIV/AIDS in Zhongshan city, the HIV positive rate of the spouses for the first test was high.

关 键 词：艾滋病病毒感染者/艾滋病病人 配偶 异性性传播 影响因素 

分 类 号：R373.9[医药卫生—病原生物学] R512.91[医药卫生—基础医学]